The National Eye Institute (NEI) awarded a $366,523 Project Grant under the Vision Research program (CFDA 93.867) to The University of Iowa. The grant supports research to develop a sustained delivery system for two drugs - acriflavine and pirfenidone - that address the multifactorial nature of wet age-related macular degeneration (wet AMD). The goal is to use polyurethane nanocapsules to deliver the drugs over an extended period and trigger on-demand release via ultrasound. This approach aims to better preserve retinal tissue and visual acuity by concurrently addressing neovascularization and fibrosis, two critical components of wet AMD. The project period runs from June 1, 2024 to May 31, 2028.
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