Project Grant R01ES038941
- The National Institute of Environmental Health Sciences awarded $813,303 to The Research Foundation For The State University Of New York (operating as Stony Brook University) on September 3, 2026, under the Environmental Health program (CFDA 93.113) to investigate the molecular mechanisms by which arsenic exposure amplifies ultraviolet radiation-induced skin carcinogenesis. The project, titled "Environmental Modifiers of UVR Skin Carcinogenesis: Deciphering the Effects of Mixed...
- The National Institute of Environmental Health Sciences awarded The Research Foundation For The State University Of New York $814,154 on April 1, 2026, under the Environmental Health program (CFDA 93.113) to investigate epitranscriptomic and epigenetic loops driving cellular responses to naphthalene, a respiratory toxicant and abundant component of wood smoke. The research defines the interplay between epitranscriptomic marks—RNA-based modifications regulating translation—and epigenetic...
- The National Institute of Environmental Health Sciences awarded the University of Rochester $1,433,378 on September 19, 2025, under the Environmental Health program (CFDA 93.113) to investigate airway basal cell stress mechanisms in environmentally-induced bronchiolitis obliterans following inhalation exposures to reactive diketones including diacetyl and 2,3-pentanedione. The research examines how chemical exposures damage cytoskeletal keratins in airway basal cells—the primary progenitor cells...
- The National Institute of Environmental Health Sciences awarded New York University $2,518,755 on September 16, 2025, under the Environmental Health program (CFDA 93.113) to investigate the role of NEDD9 and chromium(VI) in carcinogenesis. The research examines how chronic chromium(VI) exposure generates reactive oxygen species and impairs autophagy, leading to upregulation of NEDD9 and P62 proteins that promote malignant cell transformation and tumorigenesis in non-small cell lung carcinomas....
- The National Institute of Environmental Health Sciences awarded New York University $10.907 million on September 15, 2025, under the Environmental Health program (CFDA 93.113) to conduct a translational study on the accumulation of micro- and nanoplastic particles in mammalian tissues. The research investigates inter-tissue accumulation of micro- and nanoplastic particles across the lifespan, including the quantified concentration of these particles within systemic tissues, the role of sex, age,...
- The National Institute of Environmental Health Sciences awarded Duke University $1,006,211 under the Environmental Health program (CFDA 93.113) on February 17, 2026, to conduct research on how chemical exposures affect mitochondrial function and interact with genetic mitochondrial disease. The research employs a translational approach integrating the model organism Caenorhabditis elegans with cell culture experiments derived from mitochondrial disease patients. The work aims to define biological...
- The National Institute of Environmental Health Sciences awarded the University of Rochester $906,000 on February 19, 2026, under the Environmental Health program (CFDA 93.113) to investigate lung cellular senescence and molecular clock dysfunction induced by environmental tobacco smoke exposure. The research examines how tobacco smoke and environmental tobacco smoke disrupt the REV-ERBA molecular clock component in lung cells, triggering cellular senescence associated with chronic obstructive...
- The National Institute of Environmental Health Sciences, part of the Department of Health and Human Services National Institutes of Health, awarded $815,546 to Icahn School of Medicine at Mount Sinai on June 22, 2026, under the Environmental Health program (CFDA 93.113) to investigate how early-life chemical exposures affect executive function and brain development across adolescence. The research leverages naturally shed deciduous teeth as biomarkers to measure in utero and early childhood...
- The National Institute of Environmental Health Sciences awarded Weill Medical College of Cornell University $100,228 on October 4, 2026, under the Environmental Health program (CFDA 93.113) to investigate how bimodal conformations of the SMC5/6 protein complex regulate molecular activities and anti-genotoxic functions. The project will examine the functional mechanisms of SMC5/6 using in vitro and in vivo approaches in budding yeast, with particular focus on how two distinct conformational...
- The National Institute of Environmental Health Sciences awarded $444,125 to Duke University on April 1, 2026, under the Environmental Health program (CFDA 93.113) to investigate molecular mechanisms linking inhaled silica exposure to kidney injury through lung-kidney organ crosstalk. The research addresses a critical knowledge gap in understanding how airborne silica contributes to remote kidney tubule injury and chronic kidney disease of unknown etiology, particularly in communities with...
The National Institute of Environmental Health Sciences awarded $492,022 to The Research Foundation For The State University Of New York (operating as Stony Brook University) on September 1, 2026, under the Environmental Health program (CFDA 93.113) to investigate how the environmental toxicant 1,4-dioxane drives carcinogenesis through NRF2-dependent extracellular vesicle biogenesis. The project addresses a regulatory and scientific gap: while animal studies indicate 1,4-dioxane's tumorigenic potential, its status as a human carcinogen remains unresolved. The recipient's preliminary studies reveal that 1,4-dioxane activates NRF2 signaling, which drives extracellular vesicle biogenesis and enriches vesicles with cargo that enhances epithelial-mesenchymal transition, motility, and metastasis. Chronic exposure to environmentally relevant concentrations induces malignant transformation in epithelial cells, while CRISPR-Cas9-mediated NRF2 ablation blocks this pathway. The research will pursue three specific aims: investigate the role of RAB39B in 1,4-dioxane-induced extracellular vesicle biogenesis and carcinogenicity; evaluate SDC4 in regulation of vesicle formation, composition, and function; and determine the pro-metastatic potential of 1,4-dioxane-induced vesicles in vitro and in vivo. Successful completion will establish a previously unrecognized mechanism of environmental carcinogenesis and define 1,4-dioxane as a human carcinogen. Performance occurs in Stony Brook, New York. The period of performance runs from September 1, 2026, through June 30, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $492.0k | 8/26/26 |