Project Grant R21ES038368
- Federal Grant Award Summary Duke University received a $1,006,211 Project Grant from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health program (CFDA 93.113), effective February 17, 2026 through January 31, 2034. The award supports research to understand how environmental exposures affect mitochondrial function and health, with particular emphasis on mechanisms of mitochondrial toxicity and their interactions with genetic mitochondrial disease. The...
- Federal Grant Award Summary Duke University received a $444,125 Project Grant from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health program (CFDA 93.113), awarded February 17, 2026, with completion scheduled for February 16, 2028. The project will develop an integrated computational and experimental workflow to identify endocrine-disrupting plastic additives using machine learning models. Under Aim 1, the awardee will design novel machine learning...
- Federal Project Grant Award Summary New York University School of Medicine received $847,498 in funding from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health program (CFDA 93.113) to conduct a life-course epidemiological study examining how environmental chemical exposures affect kidney development and function. The award, effective August 1, 2025, through May 31, 2030, represents a collaborative research initiative between NYU Grossman School of...
- Federal Project Grant Award Summary Duke University received a $1,636,543 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective March 17, 2026, with completion targeted for February 28, 2031. The research project, titled "Epithelial Actions of a Ubiquitin Editor Restrict Immune-Regulated Sodium Transport in Hypertension," will...
- Federal Grant Award Summary The National Institute of Environmental Health Sciences (NIEHS) under its Environmental Health program (CFDA 93.113) awarded $417,272 to the University of Maryland, College Park on September 20, 2025, for a two-year project extending through September 19, 2027. The project develops the first early-warning system to enhance dialysis community resilience against health threats from wildfires and extreme heat events (EHEs) affecting end-stage kidney disease (ESKD)...
- Federal Project Grant Award Summary Duke University received a $3.12M Project Grant from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health program (CFDA 93.113), awarded September 5, 2025, with completion targeted for September 4, 2029. The research initiative investigates the mechanisms by which per- and polyfluoroalkyl substances (PFAS) exposure impairs placental function and fetal development through disruption of mitochondrial function and...
- Federal Project Grant Award Summary The University of Michigan, Ann Arbor, received a $1,155,450 Project Grant from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health program (CFDA 93.113), awarded June 20, 2025, with completion targeted for March 31, 2030. The award supports mechanistic research investigating impaired epithelial regeneration and progressive lung fibrosis resulting from silica and asbestos dust inhalation. The project will examine...
- Federal Grant Award Summary Duke University's Office of Research Administration received a $832,783 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective February 1, 2026, through November 30, 2029. The research project will define cellular and molecular signatures of inflammation associated with chronic kidney disease (CKD) development in people...
- Federal Grant Award Summary East Tennessee State University received a $416,750 Project Grant from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health program (CFDA 93.113) awarded on September 23, 2025, with completion scheduled for September 22, 2027. The grant funds research investigating the direct effects of per- and polyfluoroalkyl substances (PFAS) on renal hemodynamics and kidney disease mechanisms. The research employs two rat strains with...
- Federal Grant Award Summary The National Institute of Environmental Health Sciences (NIEHS) awarded the University of North Carolina at Chapel Hill a $249,000 Project Grant effective September 12, 2025, through August 31, 2028, under the Environmental Health program (CFDA 93.113). This research initiative investigates the associations between prenatal exposure to phthalates and phthalate alternatives—ubiquitous endocrine-disrupting chemicals—and cardiometabolic development in fetuses and...
Duke University received a $444,125 Project Grant from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health program (CFDA 93.113), awarded April 1, 2026, with completion targeted for March 31, 2028. The award funds preclinical research investigating molecular mechanisms of organ crosstalk and kidney injury resulting from inhaled silica exposure. The research will employ complementary functional assays to document kidney injury and examine whether circulating microRNAs (miRs) are altered early after silica inhalation, with the objective of identifying nephrotoxic mediators released from damaged lung tissue into the bloodstream that indirectly injure kidney cells. This research addresses a critical public health knowledge gap regarding how occupational and environmental silica dust exposures contribute to chronic kidney disease, particularly chronic kidney disease of unknown etiology (CKDu) reported across tropical regions and populations experiencing high heat exposure. The project will generate mechanistic insights into interorgan communication pathways that mediate remote organ injury following environmental exposures, with findings intended to inform strategies for reducing disease burden among vulnerable populations exposed to respirable silica and other airborne hazards.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $444.1k | 3/31/26 |