Project Grant R01ES038131
- The National Institute of Environmental Health Sciences awarded New York University $497,998 on June 2, 2026, to investigate the epigenetic and genetic regulation of arsenic methylation and arsenic-related cardiovascular disease risk in Native American populations under the Environmental Health program (CFDA 93.113). The research examines how DNA methylation and microRNAs influence arsenic biomethylation efficiency and downstream cardiovascular disease risk, leveraging biospecimens and...
- The National Institute of Environmental Health Sciences awarded The University of Chicago $435,145 on July 11, 2026, under the Environmental Health Program (CFDA 93.113) to develop capability and infrastructure for measuring arsenic species, including trivalent and pentavalent forms, in human cells collected from Bangladeshi individuals with varying arsenic exposure levels. The research addresses limitations in prior studies that focused primarily on measuring arsenic species in urine and blood,...
- The National Institute of Environmental Health Sciences awarded $492,022 to The Research Foundation For The State University Of New York (operating as Stony Brook University) on September 1, 2026, under the Environmental Health program (CFDA 93.113) to investigate how the environmental toxicant 1,4-dioxane drives carcinogenesis through NRF2-dependent extracellular vesicle biogenesis. The project addresses a regulatory and scientific gap: while animal studies indicate 1,4-dioxane's tumorigenic...
- The National Institute of Environmental Health Sciences awarded Trustees of Boston University $100,228 on November 13, 2026, under the Environmental Health program (CFDA 93.113) to investigate the longitudinal effect of arsenic on DNA methylation and blood pressure in pediatric populations. The research leverages secondary data from the Bangladesh Environmental Research in Children's Health (BIRCH) cohort, which enrolled participants aged 5–7 years and followed them into adolescence. The study...
- The National Institute of Environmental Health Sciences awarded New York University $2,518,755 on September 16, 2025, under the Environmental Health program (CFDA 93.113) to investigate the role of NEDD9 and chromium(VI) in carcinogenesis. The research examines how chronic chromium(VI) exposure generates reactive oxygen species and impairs autophagy, leading to upregulation of NEDD9 and P62 proteins that promote malignant cell transformation and tumorigenesis in non-small cell lung carcinomas....
- The National Institute of Environmental Health Sciences awarded $612,748 to Luxbiome Inc. on September 12, 2025, under the Environmental Health program (CFDA 93.113) to develop microbiome-based solutions for reducing inorganic arsenic exposure and body burden. The project will optimize human gut bacterial strains and evaluate their efficacy and safety in reducing arsenic uptake, methylation, and efflux through in vitro screening and in vivo modeling. Specific aims include screening bacterial...
- This Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) Federal Grant Program provides $379,504 to the University System of New Hampshire's Keene State College to conduct research on the tissue-specific development of toxicity in response to transgenerational chronic arsenic exposures. The key objectives are to: (1) detect tissue-specific uptake of arsenic in response to transgenerational chronic exposure; (2)...
- The National Institute of Environmental Health Sciences awarded The Johns Hopkins University $787,370 on August 28, 2026, under the Environmental Health program (CFDA 93.113) to investigate the effects of gestational arsenic exposure on maternal cardiovascular health. The research addresses gaps in understanding how naturally-occurring arsenic disrupts maternal heart function during and after pregnancy. The project will define effects of gestational arsenic exposure on the maternal heart...
- The National Institute of Environmental Health Sciences awarded The Research Foundation For The State University Of New York $814,154 on April 1, 2026, under the Environmental Health program (CFDA 93.113) to investigate epitranscriptomic and epigenetic loops driving cellular responses to naphthalene, a respiratory toxicant and abundant component of wood smoke. The research defines the interplay between epitranscriptomic marks—RNA-based modifications regulating translation—and epigenetic...
- The National Institute of Environmental Health Sciences awarded New York University School of Medicine $3.234 million on June 20, 2026, under the Environmental Health program (CFDA 93.113, Assistance Listing R01ES037626) to investigate the molecular mechanisms by which nickel exposure disrupts transcriptional regulation and causes lung disease. The research examines how nickel compounds, prevalent in industrial processes and consumer products including stainless steel and batteries, drive...
The National Institute of Environmental Health Sciences awarded $813,303 to The Research Foundation For The State University Of New York (operating as Stony Brook University) on September 3, 2026, under the Environmental Health program (CFDA 93.113) to investigate the molecular mechanisms by which arsenic exposure amplifies ultraviolet radiation-induced skin carcinogenesis. The project, titled "Environmental Modifiers of UVR Skin Carcinogenesis: Deciphering the Effects of Mixed Exposures," will test the hypothesis that arsenic disrupts the nucleotide excision repair pathway, impairing cyclobutane pyrimidine dimer repair and increasing mutation burden when combined with solar ultraviolet radiation exposure. Research will focus on how arsenic-induced disruption of zinc finger motifs in DNA repair proteins leads to enhanced C>T mutations in gene-regulatory regions of cancer-relevant genes, and will evaluate whether supplemental zinc can attenuate these effects. The work addresses a public health gap: over 200 million people worldwide are chronically exposed to arsenic in drinking water at concentrations exceeding EPA and WHO safety standards. Work is performed at Stony Brook, New York, with a period of performance from September 3, 2026, through August 31, 2031. The Research Foundation For The State University Of New York serves as the administrative recipient, with Stony Brook University as the performing institution. The award is classified as a Project Grant, the standard NIH R01 mechanism for supporting research by named principal investigators.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $813.3k | 9/2/26 |