Project Grant R01ES036986

Award Date 12/1/24
Completion Date 11/30/29
Dollars Obligated $696K
Federal Grant Program
93.113
Assistance Type
Project Grant
Place of Performance
Little Rock, AR 72202, USA
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This federal Project Grant award, provided by the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program, supports research to define the neurotoxic and neurodevelopmental health risks of per- and polyfluoroalkyl substances (PFAS). The $546,350 award, effective January 13, 2025 through October 31, 2029, aims to characterize the mechanisms by which PFAS affect brain development and function. Key objectives include defining PFAS uptake...
This Project Grant award from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health (CFDA 93.113) program, will fund research at Wayne State University to investigate how exposure to per- and polyfluoroalkyl substances (PFAS) impacts placental health and susceptibility to infection-mediated preterm birth. The $1,651,801 award, effective September 5, 2024 through June 30, 2029, will allow the principal investigator, Dr. Petriello, to study how PFAS...
This Project Grant award from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health program (CFDA 93.113), provides $474,639 to North Carolina State University (NC State) to conduct research on the health effects of perfluoroalkyl and polyfluoroalkyl substances (PFAS) mixtures. The project aims to develop innovative spatial and tensor-based causal inference methods to enhance the understanding of PFAS exposure and its impacts on population health....
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This Project Grant award from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health (CFDA 93.113) federal grant program, provides $695,853 to the Arkansas Children's Research Institute (ACRI) from December 1, 2024 to November 30, 2029. The project will investigate the impact of prenatal and postnatal exposure to per- and polyfluoroalkyl substances (PFAS) on children's development, examining the role of placental function and the potential protective effects of maternal exercise. Key elements include:

  • Leveraging multiple existing cohorts to robustly examine how prenatal PFAS exposures impact placental molecular regulation and associate with child growth and development, while also quantifying postnatal PFAS exposure to assess the combined impacts.
  • Conducting a randomized controlled trial to test whether increased maternal physical activity during pregnancy can reduce prenatal PFAS burden or mitigate adverse effects on offspring outcomes.
  • Involving sub-awardees from Emory University and the University of Kentucky Research Foundation to provide specialized expertise in epigenomics, PFAS quantification, and statistical analyses.

This comprehensive, transdisciplinary research aims to elucidate the mechanisms linking PFAS exposures to child health and explore potential interventions to reduce risks.

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