This Project Grant award from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health (CFDA 93.113) program, provides $143,331.00 to Wayne State University to conduct research investigating the impact of per- and polyfluoroalkyl substances (PFAS) exposure on male reproductive health. The research aims to uncover the molecular mechanisms by which PFAS mixtures affect spermatogenesis, sperm epigenetics, and extracellular vesicles called epididymosomes. Key...
This federal Project Grant award from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health (CFDA 93.113) program, provides $626,812 to the University of Illinois to investigate novel cytoplasmic remodeling mechanisms during the vertebrate oocyte-to-embryo transition. The research aims to: 1) determine the evolutionary conservation of remodeling the endoplasmic reticulum, regulated mRNA-ER association, and RNA phase transition during this critical...
This federal Project Grant award from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health (CFDA 93.113) program, provides $719,892 to New York University (NYU) to conduct research on the impact of phthalate and bisphenol exposure on infant reproductive development during a critical early life stage known as "minipuberty." The research project will enroll 480 infants and their mothers, collecting urine, blood, and breast milk samples to...
This federal Project Grant award from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health (CFDA 93.113) program, provides $466,470.00 to the University of Arizona to conduct research on the impact of phthalate exposures on female reproduction and metabolism. The key objectives of this 5-year research project are to investigate the mechanisms by which phthalate mixtures, found in common consumer products, lead to metabolic and reproductive disorders...
This Project Grant award of $227,449 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) supports research to investigate paternal age effect (PAE) mutations and their potential impact on spermatogonial stem cell clonality and reproductive aging. The key objectives of the research are to: 1) lineage trace individual spermatogonial stem cell (SSC) contributions to...
This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under CFDA 93.865 - Child Health and Human Development Extramural Research provides $1,279,780.00 to Wayne State University to study the mechanisms of the MEIG1 complex in mammalian spermiogenesis and fertilization. The key objectives are to: Dissect the motor-based complex in the manchette and its role in sperm formation Establish an in vivo system to investigate protein...
The National Institutes of Health (NIH) National Institute of Environmental Health Sciences (NIEHS) awarded a $1,999,075 Project Grant (CFDA 93.113 Environmental Health) to The Feinstein Institutes for Medical Research on September 1, 2023. The purpose of this 3-year grant is to investigate phthalate exposure and its mechanisms of action in the neonatal intensive care unit (NICU) environment. Specifically, the project aims to: 1) determine the pharmacokinetic profile of common phthalate...
This Project Grant award from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health (CFDA 93.113) program, will fund research at Wayne State University to investigate how exposure to per- and polyfluoroalkyl substances (PFAS) impacts placental health and susceptibility to infection-mediated preterm birth. The $1,651,801 award, effective September 5, 2024 through June 30, 2029, will allow the principal investigator, Dr. Petriello, to study how PFAS...
This Project Grant award of $749,901, funded by the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program, aims to elucidate the origins of the mutational landscape in cancer. The research project will integrate cellular DNA adductomics, nanopore sequencing, and single-molecule duplex sequencing to investigate how exposure to environmental mutagens, such as 1,2,3-trichloropropane, bromochloroacetic acid, and furan, contributes to the...
This Project Grant award of $459,522 from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) Federal Grant Program will support research by Michigan State University (MSU) to investigate the relationship between consumption of ultra-processed foods (UPFs) and exposure to endocrine disrupting chemicals (EDCs) during pregnancy. The study will use previously collected data from the Illinois Kids Development Study (I-KIDS) pregnancy cohort...