This Project Grant award from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health (CFDA 93.113) program, aims to define the neurotoxic and neurodevelopmental health risks associated with exposure to per- and polyfluoroalkyl substances (PFAS). The $546,350 grant, awarded on January 13, 2025, will support a research study to investigate the mechanisms of PFAS uptake by neurons, the neurotoxic effects of PFAS exposure, and the impacts of PFAS on neurodevelopment and complex behaviors using a zebrafish model. The grant recipient, The Research Foundation for the State University of New York (RF SUNY), will collaborate with a sub-awardee, the University of Pittsburgh, to conduct this research. The project will utilize molecular dynamics simulations, binding assays, and cellular and organismal assays to elucidate the effects of PFAS exposure on mitochondrial function, apoptosis, and neural activity. The findings are expected to provide valuable insights into the risks associated with PFAS and enable the development of effective interventions for monitoring and mitigating the impact of these ubiquitous chemicals.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $546.4k | 1/13/25 |
Grant Number | Description | Subgrantee | Prime Award | Dollars Obligated (Click to sort descending) | Updated At (Click to sort ascending) |
|---|---|---|---|---|---|
R1435322S | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Project Grant R01ES036199 | $129.6k | 3/20/25 |