This Project Grant award from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health (CFDA 93.113) program, provides $470,500 to National Jewish Health to investigate the role of airway epithelial complement in chronic beryllium disease (CBD). The key objectives are to: Determine gene expression profiling of nasal and bronchial epithelial cells in individuals with CBD, beryllium sensitization (BES), and healthy controls, with a focus on complement genes...
This $2,247,563 federal Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program aims to build more precise semantic descriptions of physical and biological processes that make up the "source to outcome" (S2O) continuum in environmental health research. The project will engage data generators, computational modelers, public health decision-makers, and standards developers to expand data and metadata...
This Project Grant award from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health (CFDA 93.113) federal grant program, totaling $407,998 and with a period of performance from September 1, 2024 to June 30, 2029, is intended to develop a new Bayesian workflow for the analysis of contaminated immunoassay data. The research aims to address limitations of current methods for estimating analyte concentrations in immunoassays, such as large measurement...
This $527,300 Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) Federal Grant Program will support research to investigate the mechanisms underlying impaired regeneration of the lung epithelium and progressive fibrosis in silicosis and asbestosis. The research aims to define distinct subsets of transitional alveolar epithelial cells and determine how specific signaling pathways prevent their differentiation...
This Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program aims to develop a high-sensitivity benzene detector for real-time environmental field surveys. The $294,253 award to Physical Sciences Inc., a for-profit R&D company in Andover, MA, will fund the engineering of a laboratory prototype to detect benzene, establish its performance, and demonstrate operations in outdoor urban environments. The...
This Project Grant award, valued at $26,000.00, was provided by the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) federal grant program. The award supports research to develop a novel experimental model of inflammatory arthritis induced by occupational exposure to crystalline silica (CSi). The key objectives are to: 1) determine if genetic predisposition is essential for CSi-induced inflammatory arthritis, and 2) assess whether CSi...
The National Institutes of Health National Institute of Environmental Health Sciences awarded a $924,612 Project Grant to the California State University, East Bay Foundation, Inc. under the Environmental Health (CFDA 93.113) federal grant program. The grant will fund research from August 2022 to July 2025 to advance chemical risk assessment and predictive toxicology through the development, validation and integration of high-throughput mechanistic in vitro assays. Specifically, the grantee will...
This $390,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research efforts at the University of Colorado-Denver to develop new methods for deriving and analyzing environmental phenotypes and their associations with human disease. The primary goals of this 5-year project are to: 1) improve the curation and optimization of phenotype pre-processing using genetic heritability, 2) leverage...
This $740,365 Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program will support research at New York University School of Medicine to: 1) evaluate the roles of metals and metal mixtures in coronary heart disease (CHD) risk; 2) assess genetic susceptibility to the effects of metals and metal mixtures on CHD risk; and 3) identify urinary metabolites associated with both CHD risk and metal exposures. The...
This $186,075 federal Project Grant award was provided by the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program. The award supports research to investigate the role of the ACOD1-itaconate immunometabolic pathway in regulating lung monocyte/macrophage inflammatory processes in environmental exposure-induced lung injury and disease. Specifically, the research aims to determine the functional effects of the ACOD1-itaconate axis on human...