Project Grant R01EB041081
- The National Institute of Biomedical Imaging and Bioengineering awarded the University of Texas at Arlington $378,411 on April 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop super-resolution tomographic imaging technology for deep tissue visualization. The project aims to overcome diffraction limits inherent in existing super-resolution imaging modalities—including super-resolution fluorescence...
- The National Institute of Biomedical Imaging and Bioengineering awarded the Regents of the University of Michigan $149,264 on March 26, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop magnetic resonance fingerprinting (MRF) technology for myocardial tissue characterization in patients with cardiac implantable electronic devices. The project addresses the clinical underutilization of cardiac MRI in CIED...
- The National Institute of Biomedical Imaging and Bioengineering awarded the University of Texas at Dallas $186,674 on August 7, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop fullwave physics-informed recurrent neural networks for ultrasound simulation, quantitative imaging, and adaptive focusing. The project addresses barriers to clinical adoption of quantitative ultrasound by developing a single...
- The National Institute of Biomedical Imaging and Bioengineering awarded the University of Texas at Dallas $486,805 on July 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop margination-mediated delivery and glutathione-triggered release mechanisms enabled by renal-clearable gold nanoparticles for fluorescence-guided surgery of brain metastases. The project addresses a clinical gap: current...
- The National Institute of Biomedical Imaging and Bioengineering awarded the University of Texas at Dallas $499,156 on June 1, 2026, to develop acoustic blood oxygen level dependent (BOLD) imaging technology for noninvasive bedside monitoring of deep brain tissue oxygenation in neonates with hypoxic brain injury. The recipient will design and validate oxygen-responsive ultrasound contrast agents—specifically hemoglobin-filled microbubbles—that function as biosensors to enable real-time,...
- The National Institute of Biomedical Imaging and Bioengineering awarded The University of Texas Southwestern Medical Center $138,813 on September 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to support Dr. Mai Thuan Huynh's transition to independent investigator status in metabolism and molecular imaging research. The award funds design, synthesis, and validation of advanced carbon tracers to image...
- The National Institute of Neurological Disorders and Stroke awarded New York University $247,300 on July 14, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop quantitative MRI methods for assessing white matter injury and repair. The project integrates multi-shell, multi-diffusion time MRI with large-scale three-dimensional electron microscopy and quantitative immunofluorescence to establish how diffusion and T2-based...
- The National Institute of Biomedical Imaging and Bioengineering awarded the Regents of the University of Minnesota $1,073,800 on April 10, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop advanced radiofrequency and gradient technologies for whole-brain functional and structural connectivity mapping at 10.5T MRI. The work addresses suboptimal RF and gradient technologies that limit the 10.5T scanner's capability...
- The National Institute of Biomedical Imaging and Bioengineering awarded the University of North Carolina at Chapel Hill $610,678 on July 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop two innovative short echo-time magnetic resonance imaging technologies for advanced functional MRI applications. The recipient will develop, optimize, and benchmark SORDINO (steady-state on-the-ramp detection of...
- The National Institute of Biomedical Imaging and Bioengineering awarded the Regents of the University of Michigan $184,468 on August 19, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop and validate a magnetic resonance imaging technique for measuring water velocity distribution in brain tissue. The project addresses impaired glymphatic clearance in neurodegenerative diseases including Alzheimer's,...
The National Institute of Biomedical Imaging and Bioengineering awarded The University of Texas Southwestern Medical Center $536,853 on September 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286). The award funds development and validation of a comprehensive 7 Tesla MRI framework for simultaneous high-resolution mapping of brain iron and myelin in mesoscale brain structures. The project integrates three complementary technical innovations: a novel dynamic magnetization transfer sequence enabling submillimeter quantification of myelin macromolecule fraction with low specific absorption rate; a motion-robust multiparametric acquisition framework combining dynamic magnetization transfer and multi-echo gradient-echo echo-planar imaging with self-supervised deep-learning reconstruction and navigator-based motion correction to simultaneously acquire myelin-sensitive and iron-sensitive biomarkers; and a unified quantitative model combining myelin macromolecule fraction, R2*, and quantitative susceptibility mapping measurements to improve susceptibility source separation and estimate paramagnetic iron and diamagnetic myelin contributions. The framework addresses iron dysregulation and myelin degeneration in neurodegenerative and demyelinating disorders including Alzheimer's disease and multiple sclerosis by enabling detection of early pathological changes in cortical layers and hippocampal subfields. Work is performed in Dallas, Texas. The period of performance runs through May 31, 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $536.9k | 8/27/26 |