Project Grant R01EB039768
- The National Institute of Biomedical Imaging and Bioengineering awarded Virginia Polytechnic Institute & State University $563,970 on August 19, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop an ultrasound-guided handheld histotripsy system for precise and tissue-selective thyroid ablation. The project targets thyroid tumors using histotripsy, a non-thermal ultrasonic therapy method that ablates tissue...
- The National Institute of Biomedical Imaging and Bioengineering awarded the University of Texas at Dallas $186,674 on August 7, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop fullwave physics-informed recurrent neural networks for ultrasound simulation, quantitative imaging, and adaptive focusing. The project addresses barriers to clinical adoption of quantitative ultrasound by developing a single...
- The National Institute of Biomedical Imaging and Bioengineering awarded Iowa State University of Science and Technology $215,723 on August 14, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop a next-generation, handheld, battery-powered, wireless dual-mode ultrasound-photoacoustic imaging system integrating high-power nanosecond pulsed light-emitting diodes. The project addresses a gap in current imaging...
- The National Institute of Biomedical Imaging and Bioengineering awarded George Mason University $265,018 on August 15, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop a disposable wearable ultrasound patch for real-time, noninvasive monitoring of cardiac output and blood pressure in neonates and infants following cardiac surgery. The project addresses the absence of continuous hemodynamic monitoring solutions...
- The National Institute of Biomedical Imaging and Bioengineering awarded the University of Texas at Arlington $378,411 on April 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop super-resolution tomographic imaging technology for deep tissue visualization. The project aims to overcome diffraction limits inherent in existing super-resolution imaging modalities—including super-resolution fluorescence...
- Federal Project Grant Award Summary Virginia Polytechnic Institute & State University (Virginia Tech) received a $428,578 Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286). The award, effective September 1, 2025 through August 31, 2027, supports research into focused ultrasound (FUS) therapies for non-invasive treatment of...
- The National Institute of Biomedical Imaging and Bioengineering awarded Vanderbilt University $542,947 on March 3, 2026, to develop fully non-invasive transcranial functional ultrasound imaging for adult humans under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286). The project applies signal processing and machine learning techniques to enhance low-velocity blood flow imaging through the skull, translating functional ultrasound...
- The National Science Foundation Division of Civil, Mechanical, and Manufacturing Innovation awarded Virginia Polytechnic Institute & State University $395,099 on September 1, 2026, under the Engineering program (CFDA 47.041) to investigate remote actuation of liquid crystal elastomers using focused ultrasound. The research establishes a predictive framework for ultrasound-driven actuation of liquid crystal elastomers—soft polymers that undergo large, reversible shape changes when their...
- The National Institute of Biomedical Imaging and Bioengineering awarded the University of North Carolina at Chapel Hill $570,612 on April 7, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop advanced volumetric ultrasound systems for functional imaging and multi-targeted closed-loop neuromodulation. The project addresses current limitations in ultrasonic neuromodulation by moving beyond MRI-dependent targeting...
- The National Science Foundation Division of Chemical, Bioengineering, Environmental, and Transport Systems awarded Virginia Polytechnic Institute & State University $499,996 on February 15, 2026, under the Engineering program (CFDA 47.041) to develop in vivo mapping of reproductive tissue remodeling during pregnancy using diffusion MRI. The project integrates advanced medical imaging, computational modeling, and machine learning to track how cervical and vaginal tissue structures change...
The National Institute of Biomedical Imaging and Bioengineering awarded Virginia Polytechnic Institute & State University $750,993 on September 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop accurate, robust, and practical pulse-echo speed-of-sound imaging methods for clinical ultrasound applications. The project combines physics-based inversion and deep learning approaches to enable two-dimensional, real-time mapping of sound speed distribution in tissue using standard ultrasound probes. Current pulse-echo methods yield only average speed-of-sound estimates or one-dimensional depth profiles and lack the two-dimensional visualization required for heterogeneous tissue characterization. The research addresses barriers in accuracy, computational efficiency, ground truth validation, dataset availability, and generalizability by leveraging large-scale synthetic dataset generation and information-theoretic principles. Speed-of-sound imaging has demonstrated potential for characterizing breast cancer, liver steatosis, musculoskeletal disease, and other conditions, and can improve image quality through aberration correction for conventional B-mode and emerging technologies including ultrafast Doppler and super-resolution imaging. Performance occurs in Blacksburg, Virginia. The period of performance runs from September 1, 2026, through May 31, 2030. This is a Project Grant award under the NIH assistance type classification.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $751.0k | 8/28/26 |