The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $385,383 Project Grant under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to the California Institute of Technology (Caltech) on December 1, 2024. The grant supports the development of an adaptive framework to rapidly synthesize and reconfigure synthetic bacterial viruses (phages) for use in phage therapy to counter antibiotic-resistant pathogens....
This Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports the development of polymer-phage nanoparticle conjugates to treat antibiotic-resistant wound biofilm infections. The $593,860 award to the University of Massachusetts aims to create new phage-polymer nanoparticles that can more effectively penetrate and eradicate bacterial biofilms compared to free phage therapies. The...
This Project Grant award of $427,625.00 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research by Washington University to discover novel anti-biofilm agents derived from bacteriophages. The goal is to develop alternative therapies for treating biofilm-associated infections, which are a major challenge for pathogens like Pseudomonas aeruginosa. The research will isolate phages that can overcome biofilm barriers,...
This $821,426 Project Grant, awarded on January 16, 2025 by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under CFDA 93.286 - Discovery and Applied Research for Technological Innovations to Improve Human Health, is funding research to develop nanostructures that selectively target bacteria and create computational models to predict their activity and behavior. The key objectives are to: Use computer-guided design to create and test antimicrobial nanostructures against...
This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award of $273,652 to Phage Refinery LLC aims to develop a rapid and efficient parametric model for predicting the likelihood that a given bacteriophage (phage) will survive sufficiently long in the presence of an active immune system to be effective as a treatment against their target bacterial infection. The project will gather physical parameters and in-vivo persistence data for 400...
This $423,500 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) aims to identify antimicrobial peptides and small molecules that can disrupt crystalline biofilms formed by Pseudomonas aeruginosa bacteriophages in cystic fibrosis (CF) patients. The goal is to promote the diffusion of inhaled antibiotics through sputum and improve the efficacy of antibiotic treatment for Pseudomonas airway infections in CF...
This Project Grant award of $305,000 from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) program supports the development of an advanced wound care product for treating diabetic foot ulcers. The product is a microneedle bandage that delivers three therapeutic agents to disinfect the wound, prevent bacterial biofilm re-formation, and activate the immune system to facilitate healing. Initial work will be conducted using skin tissue cultures and testing...
This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), is providing $208,125 to the University of Connecticut Health Center to develop an intralesional drug delivery strategy for treating infected wounds. The key products and services to be delivered include: Characterization of in situ formed microneedle-like drug depots and...
This Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $197,646 to the University of California, San Diego (UC San Diego) to conduct research on enhancing bacteriophage function with coevolution and synthetic biology. The overall objective is to use experimental evolution to identify genetic changes in phages that enhance their ability to suppress bacterial growth,...
This Project Grant award from the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) provides $2,296,000 to The Trustees of Princeton University to develop novel approaches for combating bacterial infections. The university will leverage its M3-SEQ single-cell RNA sequencing technology to monitor host-pathogen interactions at single-cell resolution, in order to identify new targets for phage therapies and host-directed interventions to treat infections...
This $625,909 Project Grant awarded by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) supports research and development of a hydrogel platform technology for delivering topical bacteriophage therapy to treat antibiotic-resistant wound infections. The award aims to develop innovative methods for sustained local delivery of bacteriophages - viruses that kill bacteria - to effectively eradicate Pseudomonas aeruginosa infections, including in chronic wounds. Key focus areas include identifying optimal phage dosing and delivery requirements, developing imaging technologies to assess phage pharmacokinetics, and engineering hydrogels for effective topical phage delivery. This research is being conducted by The Leland Stanford Junior University and is expected to be completed by April 2029.