Novel MRI coil technology for safe imaging of children with implants
Active Project Grant Awarded Last action
- Award ID
- R01EB034377
- Recipient
-
Northwestern University UEI KG76WYENL5K1
- Awarding agency
-
National Institute of Biomedical Imaging and Bioenginering
National Institutes of Health, Department of Health and Human Services
- Obligated
- $2,572,618
Award facts
- Assistance listing
- 93.286 Discovery and Applied Research for Technological Innovations to Improve Human Health
- Completion date 89% complete
- Originally
- Place of performance
- Chicago, IL 60611, USA
Award details come from USAspending.gov.
Description
- Abstract
- Magnetic resonance imaging (MRI) has revolutionized our approach to understanding human biology and pathology. Despite continuous advances, however, MRI remains largely inaccessible to a sizeable and growing group of patients who have conductive implants. The problem is exacerbated in children, for whom MR- conditional devices are not readily available, leaving this vulnerable population unable to receive the standard of care that they need the most, and excluding them from scientific inquiries when they are most advantageous. The major risk of MRI in patients with conductive implants is the RF heating of the tissue due to the antenna effect. This happens when the electric field of MRI scanner couples with the implanted device and amplifies the specific absorption rate (SAR) of the radiofrequency energy in the tissue surrounding the implant. MR-conditional implants have been approved by the FDA for adults, allowing patients to receive MRI under restricted conditions that assure safety. Regrettably, however, neither MRI vendors nor device manufacturers have established safe MRI methodologies for children with conductive implants. We propose to develop, validate, and deploy a novel multi-platform MRI coil technology that allows ultra-fast and high-resolution MRI to be safely performed in children with conductive implants regardless of the implant location in their bodies. Our solution is based on the idea that through innovative engineering we can control local electric fields generated by MRI on a case-by-case basis, thus avoiding interactions with the individual's implanted device wherever IT happens to be in the body. Our preliminary results show that this technique can achieve a 20- fold reduction in RF heating of cardiac implantable electronic devices (ceids), as well as implants of central nervous system (CNS) such as ecog electrodes and vagus nerve stimulation (VNS) devices. Such reduction in RF heating is sufficient to support all clinical and research sequences of interest in brain and body imaging. Here we propose to take this proof-of-concept to the next level and develop, implement, validate, and deploy the first reconfigurable patient-adjustable (RPA) MRI coil technology tailored for imaging infants and young children. Specifically, we propose to 1) develop and validate a patient-adjustable rotating MRI transmit coil that eliminates RF heating in children with cardiac and CNS implants, and 2) develop age-optimized close-fitting head and body receive arrays that integrate with the rotating coil and determine the range of imaging parameters that allow safe deployment of the ensemble coil system in children with implants. We are a multidisciplinary team including experts in MRI biophysics, instrumentation, and safety assessment, clinicians with expertise and resources in pediatric radiology and pediatric surgery, as well as MRI vendors and industry partners. If successful, our work brings state-of-the-art MRI accessible to children with implants. This will allow methodical analysis of device parameters in emerging applications, improve our understanding of existing indications, and brings unrestricted standard-of-care to pediatric patients with devices.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $0 | |
| Amendment | $467,452 | |
| Amendment | $467,452 | |
| Amendment | $473,694 | |
| Amendment | $582,010 | |
| Original award | $582,010 |
Subawards
| Subrecipient | Amount | Awarded |
|---|---|---|
| ANN & Robert H Lurie Childrens Hospital Of Chicago | $42,044 | |
| Technische Hochschule Mittelhessen - University Of Applied Sciences | $42,385 |
Quick answers
Who received award R01EB034377?
R01EB034377 was awarded to Northwestern University by National Institute of Biomedical Imaging and Bioenginering (National Institutes of Health) on May 1, 2023.
How much is award R01EB034377 worth?
$2,572,618 has been obligated on R01EB034377.
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