Federal Project Grant Award Summary

Albert Einstein College of Medicine received $887,696 in federal funding from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) for a project awarded February 1, 2026, with completion targeted for November 30, 2030. The award supports comprehensive proteomics research examining blood protein signatures associated with Type 2 Diabetes (T2D) and gut dysbiosis in the Hispanic and Latino population, a demographic group experiencing disproportionately high rates of T2D. The research leverages the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) cohort to profile plasma proteomes in 2,300 individuals free of diabetes at baseline, including repeated proteome measurements over approximately six years in 1,000 participants, utilizing advanced proteomic analysis methods.

The project integrates proteomics data with microbiome analysis to investigate the biological mechanisms linking gut dysbiosis to T2D risk in this understudied population. By analyzing 5,000+ proteins and correlating these findings with extensive multi-omics data, sociocultural factors, behavioral characteristics, and repeated glycemic measurements already available through the HCHS/SOL cohort, the research aims to identify novel proteomic signatures and biological pathways specific to Hispanic and Latino individuals. This investigation addresses critical knowledge gaps regarding population-specific protein-T2D associations and may identify new prevention and treatment targets for T2D in this high-risk population group.