Project Grant R01DK148457
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded $814,500 to the University of Pittsburgh on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to fund research dissecting functional decompensation of end-stage liver disease and investigating the mechanism and impact of transcription factors on long-term functional reprogramming. The research examines how the transcription factor HNF4A—which controls...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Pittsburgh $148,614 on March 9, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to conduct mechanistic studies of amino acid deprivation-induced hepatic fibrosis. The research investigates how asparagine depletion during pegylated asparaginase (PEG-ASNASE) therapy causes hepatic fibrosis, a serious form of liver injury. PEG-ASNASE is used to treat...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Pittsburgh $100,228 on December 8, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate the role of hepatocyte senescence in metabolic dysfunction-associated steatotic liver disease (MASLD). The research develops and employs a novel in vivo mouse model enabling selective induction of senescence in hepatocytes to examine the effects of...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Cincinnati Children's Hospital Medical Center $851,275 on February 15, 2026, to investigate mechanisms regulating hepatocyte plasticity and competency for reprogramming into cholangiocytes as a potential therapeutic approach for intrahepatic bile duct paucity. The research addresses the scientific barrier that hepatocytes in cholestatic stress can reprogram to form functional intrahepatic bile duct networks, but key...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Pittsburgh $597,656 on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate the role of oxidoreductase sulfiredoxin 1 (SRXN1) and protein sulfinylation in drug-induced acute liver failure. The project examines how SRXN1 and protein S-sulfinylation function as cell-type-specific responses to acetaminophen (APAP) hepatotoxicity....
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Cincinnati Children's Hospital Medical Center $822,411 on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to define population-specific requirements for the transcription factor ATF3 in repressing steatotic liver disease progression using experimental models. The funded research examines how macrophage heterogeneity contributes to steatotic liver disease,...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Pittsburgh $1.610 million on September 15, 2025, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate the role of the cystic fibrosis transmembrane receptor (CFTR) in dietary fatty acid transport in the small intestine. The research, led by Principal Investigator Alison B. Kohan and co-investigator C.A. Hodges, will test clinically relevant...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Pennsylvania $789,828 on June 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to develop theoretical models validated through experiments explaining the progression of metabolic dysfunction-associated steatotic liver disease (MASLD). The project develops and validates tissue-mechanics models to predict how cholesterol crystals in the liver drive...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Pittsburgh $698,501 on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to identify gene-level interactions between host immunity and the intestinal microbiota that regulate inflammation in inflammatory bowel disease. The funded research combines microbiota analysis tools, host single-cell RNA sequencing, and machine learning methods to...
- The National Institute of Diabetes and Digestive and Kidney Diseases, part of the National Institutes of Health within the Department of Health and Human Services, awarded Children's Research Institute $156,814 on August 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to support Project Grant K08DK149197. The award funds research defining immunomodulatory mechanisms in autosomal recessive polycystic kidney disease (ARPKD), a severe...
The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Pittsburgh $550,070 on August 15, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to conduct research elucidating ATP8B1 deficiency using patient-derived induced pluripotent stem cell (iPSC) models. The project addresses progressive familial intrahepatic cholestasis (PFIC) caused by ATP8B1 mutations, a rare inherited liver disease that impairs bile formation and frequently requires liver transplantation in childhood. Using patient-derived iPSCs carrying the common ATP8B1 G308V mutation, the research will establish hepatocyte and cholangiocyte models to investigate how FIC1 deficiency disrupts bile acid homeostasis and cellular resilience. The work will define how FXR suppression contributes to bile acid accumulation and hepatocyte vulnerability, interrogate the role of glutamine metabolism in bile acid dysregulation and test whether supplementation restores function, and evaluate whether restoring MUC1 expression improves cholangiocyte function and hepatobiliary homeostasis. Period of performance extends from August 15, 2026, through June 30, 2031. Work is performed in Pittsburgh, Pennsylvania. The award is classified as a Project Grant, a standard assistance type under the NIDDK program supporting basic and clinical research that improves understanding of disease mechanisms and leads to improved prevention, diagnosis, and treatment.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $550.1k | 8/12/26 |