Project Grant R01DK146958
- Federal Project Grant Award Summary The University of Illinois received a $325,522 Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective September 1, 2025, with a completion date of May 31, 2030. The research project investigates the effects of fructooligosacharides (FOS), a dietary fiber supplement, on preventing Western diet-induced hypothalamic...
- Federal Project Grant Award Summary The University of Chicago received a $770,995 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective February 2, 2026, through November 30, 2029. This research initiative focuses on investigating the role of heat shock protein 25/27 (HSP25/27) in intestinal epithelial cell restitution and mucosal healing...
- Federal Grant Award Summary The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded the University of Chicago a $6.51 million Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) for a four-year research initiative spanning September 2025 through September 2029. This investigation examines the role of macrophages in weight loss-induced metabolic health and adipose tissue inflammation resolution. The research...
- Federal Grant Award Summary The University of Illinois received a $1.62 million Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective July 1, 2025, through April 30, 2030. The award supports research investigating how growth hormone (GH)-regulated STAT5 signaling and sex-dependent transcription factors protect females from metabolic...
- Federal Grant Award Summary The University of Chicago received a Project Grant award of $147,486 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) for the period of September 30, 2025, through September 29, 2028. The grant funds basic biomedical research investigating the regulation of exocrine pancreatic innate immunity through microbially induced Interleukin-22...
- Federal Project Grant Award Summary The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded Washington University a Project Grant totaling $233,250 on September 15, 2025, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award supports research into the role of protein phosphatase 1K (PPM1K) in macrophage activation and metabolic disease. The research addresses a critical knowledge gap regarding branched chain amino...
- Federal Project Grant Award Summary The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded $140,116.00 to the Beckman Research Institute of the City of Hope on September 15, 2025, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to support basic biomedical research on gut-fat crosstalk in metabolic regulation through July 31, 2028. The research project investigates the mechanisms of communication between the intestine...
- Federal Project Grant Award Summary The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded The Washington University a $709,931 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) effective August 15, 2025, with a completion date of June 30, 2030. This award supports investigator-initiated basic biomedical research investigating neutrophil regulation of brown adipose tissue (BAT) homeostasis and its implications...
- Federal Grant Award Summary The National Institute of Diabetes and Digestive and Kidney Diseases awarded a $778,662 Project Grant to the University of California, Los Angeles (UCLA) effective April 6, 2026, through January 31, 2030, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). This research initiative examines the genetic and gut microbial regulation of indole-3-propionic acid (IPA), a bacterial metabolite derived from dietary tryptophan, and...
- Federal Grant Award Summary Northern Illinois University received a $554,874 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective August 15, 2025, through July 31, 2028. The research project investigates the gut-brain-microbiota axis and its role in the relationship between inflammatory bowel disease (IBD) and chronic stress. The primary...
The University of Illinois received a $786,728 Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective June 1, 2026, through April 30, 2031. The award supports basic biomedical research investigating gut microbiota-derived 3-phenylpropionic acid (3-PPA) as a metabolic modulator of beige adipogenesis and energy homeostasis. The research integrates metabolic physiology, immunometabolism, and microbiota signaling to elucidate disease mechanisms governing thermogenic fat function in the context of obesity and metabolic dysfunction. The funded research will characterize GPR40-mediated signaling in macrophages during 3-PPA-induced metabolic remodeling, define how CXCL13–T follicular helper cell interactions influence beige adipogenesis in obesity, and assess the therapeutic efficacy of 3-PPA-based interventions in mouse models of diet-induced obesity and metabolic disease. These research activities aim to uncover the microbiota-immune-adipose signaling axis as a potential foundation for novel therapeutic approaches to mitigate obesity and associated metabolic disorders. The research will be conducted at the University of Illinois Chicago campus.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $786.7k | 6/3/26 |