Project Grant R01DK146907
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Henry Ford Health+Michigan State University Health Sciences (Michigan State University) $157,000 under Project Grant R03DK147443 on May 1, 2026, to develop targeted nanotheranostics for beta-cell protection in type 1 diabetes. The project designs iron oxide nanoparticle-based nanodrugs functionalized with exendin-4 peptides to target glucagon-like peptide-1 receptors on pancreatic beta-cells. The nanodrugs will...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Wayne State University $1.137 million on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to establish a database characterizing phosphorylation and O-linked N-acetylglucosamine (O-GlcNAc) glycosylation differences in skeletal muscle tissue between insulin-sensitive and insulin-resistant individuals. The research examines crosstalk between reversible...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), a component of the Department of Health and Human Services National Institutes of Health, awarded the Regents of the University of Michigan $1,519,835 on September 24, 2025, to test a novel weight navigation program designed to overcome multilevel barriers to obesity treatment in primary care settings. The project grant (R01DK139094) supports research under the Diabetes, Digestive, and Kidney Diseases Extramural...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded $1,539,726 to the Regents of the University of Michigan on September 15, 2025, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to conduct multi-ancestry whole-genome sequencing analyses of metabolic dysfunction-associated steatotic liver disease (MASLD) with functional follow-up studies. The project performs genome-wide association studies across multiple ancestries using...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Wayne State University $116,250 on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award funds research into the role of MAFA and MAFB transcription factors in maintaining human pancreatic beta cell maturity and function through histone methylation. The research tests the hypothesis that these transcription factors regulate gene expression via...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded The Broad Institute, Inc. $1,647,485 on September 19, 2025, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to conduct massive-scale genomic risk assessment across monogenic and common forms of diabetes. The award will support analysis of the largest dataset of rare variation linked to diabetes phenotyping, comprising more than 1.1 million participants (33 percent...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the Regents of the University of Michigan $672,600 on August 25, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate the neural circuits that control glucose mobilization through the hypothalamus. The project, R01DK143970, will identify distinct populations of dorsomedial ventromedial nucleus neurons and determine how specific neural subtypes coordinate...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the Regents of the University of Michigan $785,969 on February 6, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate secretory pathway protein degradation mechanisms that maintain insulin biogenesis and secretion in pancreatic beta cells. The award funds research into how pancreatic beta cells maintain approximately one billion insulin molecules per cell...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the Regents of the University of Michigan $616,132 on August 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to develop nanocarrier-based immunotherapeutic strategies for type-1 diabetes treatment. The research targets immune tolerance induction against type-1 diabetes through biomaterial nanocarriers designed for lymph node targeting, a key site for immune...
- The National Institute of Diabetes and Digestive and Kidney Diseases, an institute within the Department of Health and Human Services National Institutes of Health, awarded the Regents of the University of Michigan $690,854 on February 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award funds research to identify molecular and genetic mechanisms that determine and maintain kidney epithelial cell states in normal physiology and in...
The National Institute of Diabetes and Digestive and Kidney Diseases awarded Michigan State University (doing business as Henry Ford Health+Michigan State University Health Sciences) $696,622 under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) on September 1, 2026. The award supports pharmacogenomic discovery research on type-2 diabetes treatment response using big data approaches among patients from Southeast Michigan and metropolitan Detroit. The research leverages the Diabetes Multi-Omic Investigation of Drug Response (DIAMOND) study cohort, which comprises 4,783 individuals with type-2 diabetes. The project investigates treatment response and pharmacogenomic outcomes for glucagon-like peptide 1 receptor agonists and sodium-glucose cotransporter 2 inhibitors in a diverse population-representative sample, addressing gaps in clinical trial generalizability across demographic subgroups and genetic structures. The period of performance runs through June 30, 2031, with work performed in East Lansing, Michigan. The funding supports basic and clinical research advancing understanding of diabetes etiology, pathogenesis, prevention, and treatment mechanisms under the NIDDK's Diabetes, Endocrine, and Metabolic Diseases research portfolio.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $696.6k | 8/20/26 |