Project Grant R01DK146326
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Northwestern University $794,032 on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate mechanisms of intestinal barrier dysfunction in people living with HIV on antiretroviral therapy and to evaluate restoration of the glycan A1,2-fucose as a therapeutic intervention. The research addresses persistent gut leakiness and microbial translocation in...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Baylor College of Medicine $240,000 on August 27, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to develop preclinical mouse models expressing HIV proteins that replicate metabolic comorbidities observed in persons living with HIV, including obesity, cardiovascular disease, chronic kidney disease, osteoporosis, cancers, frailty, and cognitive decline. The research...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Texas Biomedical Research Institute $905,998 on September 1, 2026, to investigate epigenetic mechanisms driving intestinal epithelial dysfunction in people living with HIV receiving antiretroviral therapy, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The research examines how aberrant DNA methylation and altered chromatin accessibility in colonic epithelium contribute...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Tulane University $840,005 on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate the role of aryl hydrocarbon receptor (AHR) signaling in intestinal barrier function and inflammation during antiretroviral therapy-suppressed simian immunodeficiency virus infection. The research defines how gut AHR signaling preserves epithelial barrier...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded The University of Chicago $770,995 on February 2, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate the role of intestinal epithelial heat shock protein 25/27 in mucosal healing following inflammatory injury of the bowel. The research addresses mechanisms underlying mucosal restitution in inflammatory bowel disease, ischemic colitis, and radiation-induced...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded the University of Illinois $882,709 on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate adipose tissue dysfunction in simian immunodeficiency virus (SIV)-infected rhesus macaques treated with combination antiretroviral therapy (cART). The research addresses lipodystrophy and metabolic complications that affect over 75% of chronic HIV...
- The National Institute of Diabetes and Digestive and Kidney Diseases, part of the Department of Health and Human Services National Institutes of Health, awarded $651,082 to Regents of the University of Michigan on June 15, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award funds research investigating how human intestinal stem cells reactivate developmental gene expression programs during injury repair and regeneration. The project tests...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded The Regents of the University of California, San Francisco $194,076 on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award funds a multi-omic investigation of the gut-liver axis in HIV-related liver disease. The project will define mechanistic and biomarker pathways along the gut-liver axis that contribute to and predict hepatic fibrosis in people...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Northwestern University $679,530 on March 15, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847, Project Grant R01DK142814) to characterize the anatomy, composition, and function of erythroblastic islands in mice and humans using spatial mapping technologies. The research employs unbiased spatial transcriptomic and multi-modal spatial mapping approaches to examine...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Pennsylvania $798,039 on March 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate self-organization in the intestinal epithelium. The award funds research into how enterocytes adopt specialized functions along the villus axis through a process called zonation. The project challenges conventional understanding by hypothesizing that...
The National Institute of Diabetes and Digestive and Kidney Diseases awarded Northwestern University $811,941 on September 3, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to develop three-dimensional intestinal organoid models that investigate the bidirectional relationship between HIV transcription and intestinal barrier function in people living with HIV. The research uses complementary organoid platforms: patient-derived organoids isolated from intestinal biopsies that preserve donor-specific characteristics and disease phenotypes, and induced pluripotent stem cell-derived intestinal organoids that enable high-throughput genetic manipulation and include mesenchymal layers critical for gut-immune interactions. The first research aim examines how HIV transcription influences intestinal inflammation and barrier integrity by co-culturing organoids with HIV-infected CD4+ T cells from both people living with and without HIV. The second aim investigates how the intestinal microenvironment influences HIV transcription through comprehensive transcriptional and metabolic analyses. The project establishes experimental platforms for mechanistic dissection of HIV-gut interactions and development of novel therapeutic interventions, addressing how intestinal barrier dysfunction drives systemic inflammation that contributes to HIV persistence and comorbidities. Work is performed in Chicago, Illinois with a period of performance through June 30, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $811.9k | 9/2/26 |