Project Grant R01DK145882
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded $127,206 to The Washington University on April 5, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The research investigates Prevotella copri-mediated effects of dietary glycan supplementation on microbial community and host metabolism in the context of treating childhood undernutrition. The work builds on clinical trial evidence that microbiota-directed complementary...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded The Washington University $930,888 on September 15, 2025, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate how commensal fungi promote intestinal wound repair by modulating host metabolites. The research uses conditional knockout mice, single-cell RNA sequencing, primary epithelial and fibroblast cultures, and metabolomics to examine two primary aims: how...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded The Washington University $388,750 on April 23, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate the structural and functional mechanisms of podocin in glomerular membrane organization and kidney disease. The research applies detergent-free, vesicle-based cryo-electron microscopy to determine the full-length structure of podocin at near-atomic resolution...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Pittsburgh $698,501 on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to identify gene-level interactions between host immunity and the intestinal microbiota that regulate inflammation in inflammatory bowel disease. The funded research combines microbiota analysis tools, host single-cell RNA sequencing, and machine learning methods to...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of California, Davis $180,109 on June 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate restoration of microbiota signaling pathways using non-biotic substitutes—termed "faux-biotics"—to control opportunistic infections during chemotherapy-induced dysbiosis. The project addresses the loss of colonization resistance that occurs...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded The Johns Hopkins University $614,186 on August 20, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate the role of intestinal microbiota and immune cell trafficking in acute kidney injury repair. The research examines mechanistic pathways by which immune cells mediate recovery from severe acute kidney injury via microbiome-mediated migration from the...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded The Washington University $547,349 on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate the mechanisms of E. coli alpha-hemolysin toxicity to renal epithelium. The project, R01DK142175, examines how uropathogenic E. coli (UPEC) employs the secreted toxin alpha-hemolysin (HlYA) to damage kidney tissue during urinary tract infections,...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Emory University $100,228 on April 15, 2027, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The research evaluates deterministic strain interactions and stochasticity in gut microbiomes using a specialized host-microbe model system pairing squash bugs (Anasa tristis) with their mutualistic gut bacterium (Caballeronia spp.). The project assesses how bacterial competition and...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded The Washington University $165,104 on February 2, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to support basic research on mechanisms of HDL-mediated lipopolysaccharide neutralization and intestinal HDL transport into portal venous circulation. The recipient will characterize the protein and lipid constituents of LPS-neutralizing complexes using proteomics and...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Versiti Blood Health, Inc. $127,500 on February 5, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate the role of force-directed lipid metabolism in the endothelial-to-hematopoietic transition. The research examines how mechanical forces from blood flow drive hematopoietic stem cell production through the endothelial-to-hematopoietic transition in...
The National Institute of Diabetes and Digestive and Kidney Diseases awarded The Washington University $821,816 on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate the microbial contributors to hematopoiesis and the mechanisms by which commensal intestinal bacteria maintain normal blood cell production. The research interrogates how depletion of commensal bacteria causes cytopenias (low peripheral blood counts) in patients undergoing chemotherapy, transplant, or long-term antibiotic treatment. The work employs both a noninterventional pediatric clinical study and murine models to define the clinical, microbial, metabolomic, and cytokine correlates of antibiotic-induced cytopenia and to identify the bacterial metabolites and signaling pathways—particularly RIG-I-like receptor/MAVS-induced type I interferon signaling—underlying the microbiota's effects on bone marrow hematopoietic progenitors and peripheral white blood cell maintenance. Place of performance is St. Louis, Missouri. The period of performance runs from September 1, 2026, through May 31, 2030. The assistance type is a Project Grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $821.8k | 8/19/26 |