Project Grant R01DK145617
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded The Trustees of Columbia University in the City of New York $1,563,913 on September 11, 2025, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to support research on vascular sympathetic neurons in brown adipose tissue and their role in systemic metabolism. The recipient will develop and deploy novel mouse genetic and chemogenetic tools, improved imaging techniques, and in...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Duke University $790,119 on August 26, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate how memory formation in adipose tissue influences metabolic outcomes in obesity. The project, titled "Establishing Memory in Adipose Tissue Influences Future Metabolic Outcomes in Obesity," examines the mechanisms that drive divergent remodeling of white...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded The University of Chicago $123,000 on June 16, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to characterize adipocyte heterogeneity and response to metabolic stress. The funded research uses single-nucleus RNA sequencing and a humanized mouse model to investigate how diverse stimuli influence white adipocyte development and specification, with emphasis on...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded The Washington University $578,846 on February 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate brown adipose tissue–derived nidogen-2 as a potential diabetes therapeutic. The research addresses hyperglycemia and hypoglycemia risks in type 1 and advanced type 2 diabetes. Preliminary data show that nidogen-2, a secreted protein isolated from brown...
- The National Institute of Diabetes and Digestive and Kidney Diseases, part of the National Institutes of Health under the Department of Health and Human Services, awarded $717,030 to the University of Virginia on May 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to uncover neural circuits controlling body weight and metabolism. The research develops and applies RAMPANT (rabies afferent mapping by poly-A nuclear transcriptomics), a novel...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded The Washington University $720,353 on March 25, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847, Assistance Listing Project Grant R01DK141555). The award funds research to identify and elucidate the functioning of hypothalamic neural circuits that regulate energy balance and metabolism, with focus on obesity-associated metabolic diseases. The research targets a...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Yale University $839,770 on June 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to support cognitive and behavioral approaches to reduce binge eating and excess weight in adolescents. The award is a Project Grant with a period of performance extending through February 28, 2031, and work is performed in New Haven, Connecticut. The program promotes extramural basic...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Washington $888,773 on April 15, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847, Project Grant R01DK140210). The award funds research defining the contributions of hypothalamic microglia and perineuronal nets to obesity pathogenesis. The project investigates inflammatory activation of hypothalamic microglia in the arcuate nucleus and the loss of...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded $1,634,996 to Boston University (Trustees of Boston University, doing business as Boston University Medical Campus) on February 18, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to support research on vasculature and beige remodeling of obese adipose tissue. The research investigates how beige adipocyte recruitment and enhanced angiogenesis can counteract unhealthy...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), a component of the Department of Health and Human Services National Institutes of Health, awarded the Regents of the University of Michigan $1,519,835 on September 24, 2025, to test a novel weight navigation program designed to overcome multilevel barriers to obesity treatment in primary care settings. The project grant (R01DK139094) supports research under the Diabetes, Digestive, and Kidney Diseases Extramural...
The National Institute of Diabetes and Digestive and Kidney Diseases awarded Georgia State University Research Foundation Inc. $715,511 on August 25, 2026, to support basic research on the epigenetic regulation of sympathetic nerve innervation in adipose tissue under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The funded research investigates how DNA methylation reprograms sympathetic nervous system innervation in response to environmental cues such as cold exposure and dietary changes. The work focuses on brown and beige adipocyte thermogenesis—the process by which these cells dissipate energy as heat—as a potential obesity intervention. The research examines the role of DNMT3A-mediated DNA methylation at the UHMK1 promoter in regulating sympathetic neuron function and adipose tissue response, using genome-wide methylation profiling and RNA sequencing analysis in rodent models. Performance occurs in Atlanta, Georgia, with a period of performance from August 25, 2026, through June 30, 2031. This is a Project Grant award, the standard assistance type for NIH research funding.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 9/1/26 | ||
| Not listed | $715.5k | 8/25/26 |