Project Grant R01DK145455
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded $762,423 to the Regents of the University of Michigan on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to develop and optimize quantitative magnetic resonance fingerprinting (MRF) technology for non-invasive assessment of bladder wall tissue characteristics in neurogenic lower urinary tract dysfunction. The research addresses limitations of current...
- The National Institute of Diabetes and Digestive and Kidney Diseases, an institute within the Department of Health and Human Services National Institutes of Health, awarded the Regents of the University of Michigan $690,854 on February 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award funds research to identify molecular and genetic mechanisms that determine and maintain kidney epithelial cell states in normal physiology and in...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the Regents of the University of Michigan $777,956 on March 1, 2026, under CFDA 93.847 (Diabetes, Digestive, and Kidney Diseases Extramural Research) to develop computer vision and machine learning methods for detecting pre-cancerous dysplasia in inflammatory bowel disease patients during colonoscopy and histologic examination. Current detection of dysplasia in IBD patients is hampered by flat, irregular lesions that...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded The Washington University $766,951 on April 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to develop and validate imaging biomarkers for assessing high-risk deceased donor kidneys slated for transplantation. The project addresses kidney shortage by improving the accuracy of kidney quality assessment, reducing the approximately 2,500 procured kidneys discarded...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Regents of the University of Michigan $878,614 on March 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to develop and deploy treatment response prediction models for glomerular diseases within the Nephrotic Syndrome Study Network (NEPTUNE) framework through December 31, 2030. The award funds two precision medicine prediction models: one predicting patient response...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Mayo Clinic $694,443 on August 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to develop and validate advanced ultrasound imaging biomarkers for Crohn's disease. The award funds development of multiparametric ultrasound imaging technology combining B-mode imaging, advanced microvessel imaging technology, and echo statistical features to assess bowel inflammation and...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded In Vivo Microsystems Technologies, LLC $3,067,867 on September 19, 2025, for a Phase 2 Small Business Innovation Research project under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). IVMT will conduct a Phase 2 multi-center in-vivo study of a near-infrared fluorescently-labeled peptide heterodimer targeting EGFR and ERBB2 for detection of biliary intra-epithelial neoplasia. The...
- The National Institute of Diabetes and Digestive and Kidney Diseases, part of the Department of Health and Human Services National Institutes of Health, awarded $651,082 to Regents of the University of Michigan on June 15, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award funds research investigating how human intestinal stem cells reactivate developmental gene expression programs during injury repair and regeneration. The project tests...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Kscube, LLC $315,335 on August 21, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to develop a real-time, non-invasive urinary oxygen monitoring system for acute kidney injury prevention. The recipient will advance development of a novel continuous kidney-stress monitor for use during surgery and in intensive care units. The technology provides real-time detection of...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Washington $784,606 on August 25, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to develop highly multiplexed volumetric light sheet microscopy for thick tissue imaging. The award funds development of an innovative platform combining light-sheet microscopy with high-multiplex fluorescence imaging capable of up to approximately 35-plex imaging using...
The National Institute of Diabetes and Digestive and Kidney Diseases awarded the Regents of the University of Michigan $687,654 on August 5, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to develop dynamic contrast-enhanced ultrasound (DCEUS) as a radiation-free alternative to nuclear medicine diuretic renography for diagnosing upper urinary tract obstruction. The research addresses limitations of current diagnostic methods, which expose patients to ionizing radiation, produce unreliable results including frequent false positives and negatives, and have limited accessibility. DCEUS uses purely vascular ultrasound contrast agents to directly assess renal microvascular perfusion changes, enabling earlier detection of obstruction-related kidney injury before irreversible damage occurs. The contrast agents have an excellent safety profile with no renal or hepatic toxicity. The project aims to establish DCEUS as a reliable, more efficient, and accessible imaging method that can detect renal parenchymal changes before functional decline. Work is performed at the University of Michigan in Ann Arbor, Michigan. The period of performance runs through May 31, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $687.7k | 8/4/26 |