Project Grant R01DK144815
- This federal Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $146,922.00 to the Albert Einstein College of Medicine to investigate genotype-environment interactions that drive dysfunction in hematopoietic stem and progenitor cells (HSPCs). The research aims to decipher how HSPC dysregulation, a major driver of myeloid malignancies like myelodysplastic syndromes (MDS), is influenced by the interplay between genetic...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), through the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), awarded a $133,333 Project Grant to Yale University to study the mechanisms underlying the myeloid bias in aged hematopoietic stem and progenitor cells (HSPCs). The research aims to correct this myeloid bias by preventing the turnover of the linker histone H1.0, which could have implications for addressing diverse...
- This federal Project Grant award of $196,460 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will support research to determine how inhibiting the migration of immature neutrophils during obesity affects hematopoietic stem and progenitor cells, metabolism, and systemic inflammation. The award, made on Jun 23, 2025, is to The Trustees of Columbia University in the...
- This $133,315 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research conducted by the University of Rochester to investigate the impact of bone turnover and local inflammatory profiles on the expansion of clonal hematopoiesis (CH) in live animal models. The project aims to establish a robust methodology for tracking CH clones and skeletal dynamics through...
- This $121,473 Project Grant award from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health federal grant program (CFDA 93.113), supports research to investigate the joint effects of environmental exposures and dietary patterns on the risk of developing type 2 diabetes. The research, led by Harvard T.H. Chan School of Public Health, will leverage data from three large prospective cohorts totaling approximately 289,000 participants to disentangle the...
- This federal Project Grant award of $242,048 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant will fund research at Versiti Wisconsin, Inc. to investigate DNA damage responses and potential chromosomal abnormalities in hematopoietic stem and progenitor cells following genome editing. The goal is to enhance the understanding of genotoxicities and...
- This federal Project Grant award of $445,240 from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health federal grant program (CFDA 93.113), supports research investigating the complex interactions between prenatal metal exposures, gut microbiome composition, and telomere length attrition in childhood. The research, conducted by the Icahn School of Medicine at Mount Sinai, aims to better understand how environmental exposures and the gut microbiome...
- This federal Project Grant award of $133,328 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research at The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to dissect the roles of the PPM1D and TP53 genes in hematopoietic stem cells and clonal hematopoiesis. The research aims to understand how mutations in these genes...
- This federal Project Grant award of $783,680, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will support a research project conducted by Pennington Biomedical Research Center in Louisiana. The project aims to examine the prospective associations between blood metal mixtures, DNA methylation, adiposity, and cardiometabolic risk from the prenatal period through...
- This federal Project Grant award of $154,860 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) supports research on the mechanisms of clonal competition in age-related clonal hematopoiesis. The grant, awarded to The Children's Hospital Corporation (Boston Children's Hospital), aims to investigate factors that drive the expansion of "super-competitor" clones bearing DNMT3A mutations, which are associated with increased risk of hematologic diseases...
This federal Project Grant award of $560,100 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to elucidate how environmental exposures, such as industrial pollution and catastrophic events, lead to hematopoietic stem cell dysfunction and the progression of clonal hematopoiesis. The project, awarded to the Albert Einstein College of Medicine in Bronx, NY, will investigate whether environmental exposures accelerate hematopoietic aging and activate inflammatory pathways, as well as assess whether exposure-induced genomic instability drives inflammation and explore therapeutic potential of targeting inflammatory pathways. The award has an ultimate completion date of June 30, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $560.1k | 9/8/25 |