Project Grant R01DK141453
- This Project Grant award of $248,915 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to unravel the role of epigenetics and cytokines in type 2 diabetes among African-ancestry populations in the U.S. and Europe. The research aims to identify causal associations between DNA methylation, circulating cytokines, and diabetes risk in these populations...
- This Project Grant award from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health federal grant program (CFDA 93.113), will support research to investigate the impacts of metal exposures on the microRNA (miRNA) composition of human breast milk and the resulting effects on early childhood growth and adiposity. The $763,965 award, which will run from May 2025 to February 2030, will be provided to the Trustees of Dartmouth College to conduct this work...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), a component of the National Institutes of Health, awarded a $789,350 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to The Pennsylvania State University (Penn State) to investigate biological mechanisms of obesity in a high-risk pediatric cohort with confirmed maltreatment. The project aims to elucidate the impact of child maltreatment on obesity through...
- This federal Project Grant award of $560,100 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to elucidate how environmental exposures, such as industrial pollution and catastrophic events, lead to hematopoietic stem cell dysfunction and the progression of clonal hematopoiesis. The project, awarded to the Albert Einstein College of Medicine in Bronx, NY, will...
- This federal Project Grant award of $168,886 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will support research to elucidate the role of NAD+ and PARP1 in nephron endowment and kidney development. The 5-year project, awarded on May 1, 2025 with a completion date of January 31, 2030, will be conducted by the University of Texas Southwestern Medical Center. The...
- This $1,558,188 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will fund research to investigate how changes in transcription factor and heterochromatin states in embryos and adult livers impact hepatocyte development, homeostasis, and regeneration. The project, led by researchers at the University of Pennsylvania, will utilize advanced...
- This federal Project Grant award in the amount of $1,428,186.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), to Beth Israel Deaconess Medical Center, Inc. (Bidmc) in Massachusetts. The project aims to investigate the role of CYP4F enzymes in regulating N-acyl amino acid signaling in humans, which has implications for understanding the early...
- This federal Project Grant award of $242,048 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant will fund research at Versiti Wisconsin, Inc. to investigate DNA damage responses and potential chromosomal abnormalities in hematopoietic stem and progenitor cells following genome editing. The goal is to enhance the understanding of genotoxicities and...
- This federal Project Grant award of $641,794 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant aims to elucidate the mechanisms that protect beta-cells from DNA damage during periods of growth and adaptation, in order to maintain beta-cell homeostasis and prevent the loss of functional beta-cells, a key factor in the development of type 1 and type 2...
- This $882,180 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will support a comprehensive research effort to analyze the largest dataset of rare genetic variants associated with diabetes. The Broad Institute, Inc. will lead this project to assess variant penetrance and integrate the genomic data with high-throughput cellular assays to...
This federal Project Grant award of $783,680, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will support a research project conducted by Pennington Biomedical Research Center in Louisiana. The project aims to examine the prospective associations between blood metal mixtures, DNA methylation, adiposity, and cardiometabolic risk from the prenatal period through early childhood. The research will leverage data from four existing prospective cohorts totaling 1,542 children aged 4-16 years, with plans to discover and validate patterns in DNA methylation that may link early-life metal exposures to later-life adiposity and cardiometabolic outcomes. The project will run from Sep 1, 2025 to Aug 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $783.7k | 8/27/25 |