Project Grant R01DK144476
- This $128,286 Project Grant award, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will support research into the mechanisms of renal lipotoxicity and its contribution to the development of chronic kidney disease (CKD). The principal investigator will investigate the protective role of the FAF2 gene knockout in mitigating palmitate-induced lipotoxicity in...
- This $155,562 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to elucidate the effect of activating branched chain amino acid (BCAA) catabolism in treating acute kidney injury (AKI) and the transition to fibrosis. The award recipient, The Research Foundation for The State University of New York (Stony Brook University), will conduct research to...
- This federal Project Grant award, in the amount of $531,999.00, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award is supporting research focused on understanding the role of alternative splicing in the proximal tubules of the kidney and its relationship to the progression of diabetic kidney disease. The research will investigate how diabetes...
- This Project Grant award of $214,958 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research on the role of interferon-stimulated gene 15 (ISG15) in regulating cell death pathways during acute kidney injury (AKI). The research aims to determine how ISG15 impacts the magnitude and timing of necroptosis, a regulated cell death pathway, in proximal tubule cells...
- This federal Project Grant award of $799,952 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award supports research at Northwestern University to investigate the role of the transcription factor HNF4A in the progression of chronic kidney disease (CKD) and associated complications such as inflammation, anemia, and bone/mineral disorders. The research aims...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $200,000 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to The Washington University in St. Louis. The goal of this R56 award is to delineate the molecular mechanism regulating autophagy in Autosomal Dominant Tubulointerstitial Kidney Disease (ADTKD) caused by UMOD mutations. The university will use CRISPR/Cas9 technology to generate the first...
- This $400,000 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to understand the earliest events in podocyte injury in collagen IV nephropathies. The goal is to investigate how processing of mutant collagen IV proteins injures podocytes at early stages, leading to chronic kidney disease and renal failure. The research uses...
- This federal Project Grant award of $661,694, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to enhance the understanding of the role of the FANCD2 protein in kidney development, repair, and chronic kidney disease. The award supports research at The General Hospital Corporation, doing business as Massachusetts General Hospital, to investigate FANCD2's...
- This $2,833,514 Project Grant was awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant, titled "Renal Metabolism in AKI", will fund research to investigate changes in kidney metabolism in sepsis-associated acute kidney injury (AKI) and their impact on kidney tubule injury and recovery. The University of California, San Diego (UCSD) is the awardee...
- This $199,990 Project Grant award was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research at The Ohio State University to investigate the role of the transcriptional corepressor CTBP2 as a metabolic sensor in acute kidney injury (AKI). The key objectives are to: 1) examine how acetylation regulates the nuclear localization and activation...
This federal Project Grant award, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to investigate the molecular mechanisms driving the transition from acute kidney injury (AKI) to chronic kidney disease (CKD). The $1,491,303 award to The Washington University aims to characterize how the repression of the FOXM1-CCNF axis during tubular epithelial repair leads to cellular senescence, which may mediate the AKI to CKD transition. The 4-year project will utilize in vitro and in vivo mouse models to elucidate this novel pathway, with the goal of improving understanding and potential interventions for this debilitating disease progression.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.5m | 9/5/25 |