Project Grant R01DK144271
- This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) will support research into the role of post-transcriptional RNA modifications in lung development and regeneration. The $768,985 award, effective September 1, 2025 through June 30, 2029, will enable researchers at Columbia University's Health Sciences Division to study how the METTL3/14 complex-mediated RNA modifications, including on the SOX9 transcript, regulate lung...
- This federal Project Grant award of $1,222,594.00, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research investigating the role of glutathione peroxidase 3 (GPX3) in regulating esophageal epithelial remodeling, subepithelial fibrosis, and eosinophil recruitment in eosinophilic esophagitis (EoE). The research, led by the primary awardee Vanderbilt...
- This $715,501.00 Project Grant awarded on March 15, 2025 by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research at Columbia University's Health Sciences Division. The project aims to investigate the role of T helper cells and stem cells in colon homeostasis and tumor initiation. Key objectives include determining how T cell cytokines modulate colon stem cell...
- This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research provides $115,288 to the University of North Carolina at Chapel Hill (UNC-CH) to support research on transcriptional regulation of mitochondrial metabolism in human intestinal stem cells. The principal investigator, Dr. Joseph Burclaff, is mentored by Dr. Scott Magness. The project aims to determine how the...
- This federal Project Grant award, funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to investigate the role of rare genetic variants in the NOD2 gene in the pathogenesis of eosinophilic esophagitis (EOE). The $2,086,360 award to Children's Hospital Medical Center in Cincinnati, OH will fund a 4-year research project to examine how NOD2 variants impair epithelial...
- This federal Project Grant award of $183,600.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant will support a 5-year research and career development plan for the principal investigator, Dr. Amiko Uchida, to investigate how dietary changes impact the gut microbiome composition and function in patients with eosinophilic esophagitis (EoE), a chronic...
- This federal Project Grant award of $465,444.00, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to investigate how commensal fungi in the gut can promote intestinal wound repair. The research aims to mechanistically understand how fungi modulate epithelial cells and fibroblasts to enhance crypt regeneration, with a focus on identifying the...
- This Project Grant award of $234,000 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research at the University of Colorado-Denver to investigate the role of the Aiolos transcriptional regulator in the pathogenesis of inflammatory bowel disease. The researchers aim to utilize CRISPR-Cas9 genome editing to examine how Aiolos regulates T cell...
- This federal Project Grant award for $836,942 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research into the role of autophagy (self-digestion) in intestinal regeneration and stem cell activity. The research aims to investigate how autophagy contributes to injury resistance and the ability of certain intestinal cell types to re-acquire stem cell-like...
- This federal Project Grant award of $155,443 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research on the role of blood vessel endothelial cells in intestinal regeneration and inflammatory bowel disease. Led by Dr. Brisa Palikuqi at Yale University, the research utilizes mouse models, immune profiling, single cell RNA sequencing, and spatial transcriptomics...
This $784,280 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research program) will support research to investigate the role of post-transcriptional modifications in regulating esophageal basal cell function and regeneration. The primary recipient, The Trustees of Columbia University in the City of New York, will use a combination of mouse genetics, sequencing, and CRISPR/Cas9 techniques to identify and functionally test mRNA substrates modified by the METTL3/14 methylation complex. The research will also examine how METTL3/14-mediated modifications, including of the p63 transcript, impact basal cell-driven esophageal tissue repair and regeneration. This 5-year project, awarded on September 15, 2025, aims to elucidate the post-transcriptional regulatory mechanisms governing esophageal homeostasis and regeneration, with potential implications for diseases like eosinophilic esophagitis.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $784.3k | 9/9/25 |