Project Grant R01DK143991
- This federal Project Grant award of $154,860 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) supports research on the mechanisms of clonal competition in age-related clonal hematopoiesis. The grant, awarded to The Children's Hospital Corporation (Boston Children's Hospital), aims to investigate factors that drive the expansion of "super-competitor" clones bearing DNMT3A mutations, which are associated with increased risk of hematologic diseases...
- This $200,000 federal Project Grant award was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research at Baylor College of Medicine in Houston, Texas to investigate how proteostatic (protein homeostasis) stress influences the fate and function of hematopoietic stem cells (HSCs). The research aims to systematically map how specific proteostatic...
- This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), is for the transformation of a human-induced pluripotent stem cell (iPSC)-derived bone marrow organoid to study hematopoiesis. The key objectives are to perform cellular mapping of the organoid, optimize it for the study of hematopoietic development, and culture the organoid under specific...
- This Project Grant award of $277,089, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to improve understanding of the genetic drivers of nephrotic syndrome (NS) in order to guide clinical management and develop targeted therapies. The research, conducted by The Children's Hospital Corporation (dba Boston Children's Hospital), will investigate the...
- This federal Project Grant award of $133,328 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research at The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to dissect the roles of the PPM1D and TP53 genes in hematopoietic stem cells and clonal hematopoiesis. The research aims to understand how mutations in these genes...
- This Project Grant award of $111,513 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports high-throughput, high-resolution functional mapping of non-coding DNA sequences regulating fetal hemoglobin expression. The research aims to comprehensively characterize cis-regulatory elements and transcription factor binding sites governing the developmental switch from fetal to adult hemoglobin,...
- This federal Project Grant award of $242,048 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant will fund research at Versiti Wisconsin, Inc. to investigate DNA damage responses and potential chromosomal abnormalities in hematopoietic stem and progenitor cells following genome editing. The goal is to enhance the understanding of genotoxicities and...
- This federal Project Grant award from the National Cancer Institute (CFDA 93.398 Cancer Research Manpower) provides $223,176 to The Children's Hospital Corporation (doing business as Boston Children's Hospital) to conduct research on the role of stress granules in cancer initiation and progression. The overarching goal is to use a humanized zebrafish melanoma model to investigate how stress granules formed in melanoma precursor cells impact tumor development and oncogenicity. Specific objectives...
- This $2,024,340 Project Grant was awarded on August 15, 2025 by the National Heart Lung and Blood Institute (NHLBI), part of the National Institutes of Health, under the Cardiovascular Diseases Research federal grant program (CFDA 93.837). The grant supports a multi-year research effort at Boston Children's Hospital to optimize outcomes for hematopoietic stem cell transplantation (HCT), an essential treatment for high-risk non-malignant and malignant hematologic diseases. The research project...
- The federal Project Grant award in the amount of $617,367 was provided by the Defense Health Agency under the Military Medical Research and Development (CFDA 12.420) program. The award is being used by the Children's Hospital Corporation, doing business as Boston Children's Hospital, to conduct research on "BASE EDITING TO IMPROVE CONDITIONING AND TRANSPLANT OF BONE MARROW FAILURE PATIENTS". The research project aims to leverage innovative gene editing techniques to enhance the...
This Project Grant award, valued at $801,000.00, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The funding supports research at The Children's Hospital Corporation, doing business as Boston Children's Hospital, to investigate the role of stress granules in red blood cell development, particularly during stress conditions. The research aims to uncover the molecular mechanisms underlying efficient translation of erythroid mRNAs, focusing on the stress granule core component ATXN2 and its interactions with SRSF RNA binding proteins. Key activities include proteomic analysis, microscopy, and overexpression studies in human CD34+ cells and ALKBH5 knockout cell lines. The award has a project period from September 2025 to July 2030, with the goal of advancing the understanding of erythropoiesis regulation and potential therapeutic targets for hematological disorders.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $801.0k | 9/10/25 |