Project Grant R01DK143181
- Federal Project Grant Award Summary The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded the Regents of the University of Colorado a $551,250 Project Grant on February 19, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award, set to conclude on January 31, 2029, funds research examining vesicle fusion regulation in metabolic pathways, with particular focus on understanding how protein-protein networks...
- Federal Grant Award Summary The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded The Scripps Research Institute a Project Grant of $801,662 under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant, awarded on August 15, 2025, with completion targeted for June 30, 2029, supports basic biomedical research investigating the early initiation phase of Type 1 Diabetes (T1D), a CD4 T cell-mediated autoimmune disease. The...
- Federal Grant Award Summary The National Institute of Diabetes and Digestive and Kidney Diseases awarded The Regents of the University of Colorado–Denver a $756,480 Project Grant on September 5, 2025, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award supports a research initiative extending through June 30, 2030, that addresses critical evidence gaps in Type 2 Diabetes treatment by integrating real-world data from three health systems with...
- Federal Grant Award Summary The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded The Broad Institute of MIT and Harvard a $882,180 Project Grant on September 19, 2025, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to conduct massive-scale genomic risk assessment informing precision medicine across monogenic and common forms of diabetes. The award, with an ultimate completion date of May 31, 2030, supports analysis...
- Federal Project Grant Award Summary The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded $234,000 to the University of Colorado-Denver under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) on September 15, 2025, with a completion date of September 14, 2027. This project grant funds investigative research into the role of Aiolos, a transcriptional repressor protein, in T cell-mediated pathogenesis of inflammatory bowel disease...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $429,000 Project Grant to the University of Colorado-Denver under the Allergy and Infectious Diseases Research program (CFDA 93.855) on July 3, 2025, with a completion date of June 30, 2027. This research project delivers investigative services focused on understanding the pathogenic mechanisms of Type 1 Diabetes (T1D), specifically examining the role of pH levels in insulin-producing...
- Federal Grant Award Summary The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded $641,794 on July 21, 2025, to the Beckman Research Institute of the City of Hope under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to support research on epigenetic regulation of genomic stability in beta-cell homeostasis through April 30, 2030. The project addresses a critical gap in understanding how beta cells protect themselves from DNA...
- Federal Project Grant Award Summary The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded $4.51 million to the Regents of the University of Minnesota under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to conduct research on engineered regulatory T cells (Tregs) for Type 1 Diabetes (T1D) treatment. The project, awarded on September 5, 2025, with completion targeted for August 31, 2028, will develop "designer" Tregs...
- Federal Project Grant Award Summary The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded The Leland Stanford Junior University a $2.74 million Project Grant on September 5, 2025, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The four-year project, extending through September 4, 2029, supports basic biomedical research investigating the genetic variation underlying innate lymphoid cell (ILC) phenotypes and their...
- Federal Project Grant Award Summary Case Western Reserve University received a $107,948 Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), awarded April 21, 2025, with completion targeted for May 31, 2027. The research investigates the regulation of T cell-mediated autoimmunity in Type 1 Diabetes (T1D) by microRNA146a (miR146a), addressing a critical gap in...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a Project Grant totaling $797,416 to The Regents of The University of Colorado (University of Colorado-Denver) on April 1, 2026, for a three-year research initiative extending through March 31, 2029, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award funds research examining immunogenetic factors in the viral etiology and pathogenesis of Type 1 Diabetes (T1D), specifically investigating how genetic variability in killer cell immunoglobulin-like receptor (KIR) and major histocompatibility complex (MHC) loci influences natural killer cell and complement system function in viral-triggered islet autoimmunity and disease progression. The research deliverables include performing high-resolution DNA sequencing of the MHC and KIR genomic regions in over 2,900 at-risk children enrolled in two prospective cohort studies—the Environmental Determinants of Diabetes in the Young (TEDDY) study and a second independent cohort—using novel cost-effective, high-throughput sequencing methods. This research activity will generate genetic data and analytical findings intended to elucidate the mechanisms by which combinatorial genetic variation determines susceptibility to persistent islet autoimmunity and progression to clinical T1D following viral infection, thereby addressing a critical knowledge gap in understanding T1D etiology and potentially informing preventive and therapeutic strategies.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $797.4k | 3/16/26 |