Project Grant R01DK143170
- This Project Grant award of $1,982,628.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research to develop advanced methods for detecting liver fibrosis and creating a predictive diagnostic model for Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) in primary care settings. The project aims to improve identification of...
- This federal Project Grant award of $544,963, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to investigate the role of the protein frataxin (FXN) in metabolic dysfunction-associated steatotic liver disease (MASLD). The research conducted under this award will examine whether FXN deficiency induces and whether restoration of FXN expression prevents...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $2,999,512 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to The University of Texas Southwestern Medical Center, doing business as Southwestern Medical School. This 4-year award, starting on September 1, 2025, will support research to investigate the regulation of mitochondrial health in mammalian livers, with a focus on understanding the...
- This federal Project Grant award of $122,454, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research investigating the role of the GIMAP5 gene in maintaining liver homeostasis. The primary recipient, Yale University, is conducting studies to determine how loss of function in the GIMAP5 gene leads to capillarization and dedifferentiation of liver...
- This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), provides $309,974 to support the development of a novel, low-cost device called LIVERscope. The LIVERscope device uses advanced magnetic resonance (MR) technology to noninvasively estimate quantitative biomarkers of nonalcoholic fatty liver disease (NAFLD), including liver...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $776,863 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to the Regents of the University of Michigan. The award will fund a multi-ancestry whole genome sequencing analysis of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), a globally prevalent condition caused by excess fat accumulation in the liver. The research aims to uncover...
- This $729,085 Project Grant was awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant will fund research at the University of Utah to study the role of the EFHD1 gene in liver injury and the mechanisms by which it may impact mitochondrial function and calcium signaling. The goal is to determine if inhibiting EFHD1 could be a promising therapy for treating...
- This Project Grant award for $124,284 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research) will support research conducted by Weill Medical College of Cornell University. The key objectives are to: Develop a super-resolution deep learning framework to generate high-resolution 3D MRI volumes for enhanced monitoring of Autosomal Dominant Polycystic Kidney Disease (ADPKD), incorporating multiple...
- This $728,513 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to develop a renal quantitative susceptibility mapping (QSM) technique for reliable detection and quantification of hemorrhagic cysts as a prognostic biomarker of kidney function decline in autosomal dominant polycystic kidney disease (ADPKD). The key objective is to leverage QSM...
- This $2,638,760.00 Project Grant award was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The research aims to investigate a novel mechanism involving the metabolite rhodoquinone (RQ) and its potential role in improving mitochondrial function and mitigating metabolic diseases caused by obesity. Specifically, the project will elucidate how the RQ/fumarate...
This Project Grant, awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to develop fat and iron-corrected quantitative MRI T1 mapping techniques for evaluating chronic liver disease. Specifically, the $830,401 grant awarded to New York University will investigate the use of MRI markers, including proton density fat fraction, T2*/R2*, and MR elastography, to simultaneously assess liver fat, inflammation, and fibrosis - key aspects of metabolic-associated steatotic liver disease. The project period runs from September 15, 2025 to July 31, 2030, with the goal of establishing a novel non-invasive approach to monitor treatment response for this prevalent chronic liver condition.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $830.4k | 9/4/25 |