Project Grant R01DK142814
- Federal Grant Award Summary Northwestern University received a $799,952 Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective September 1, 2025, through May 31, 2030. The award supports basic biomedical research investigating the role of hepatocyte nuclear factor 4 alpha (HNF4A) in chronic kidney disease (CKD) progression and associated...
- Federal Project Grant Award Summary Northwestern University's Sponsored Research Division received a $188,538 Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective August 1, 2025, with completion anticipated by April 30, 2030. The award funds research focused on developing personalized biomarkers for ulcerative colitis (UC) through predictive...
- Federal Project Grant Award Summary The University of Chicago received a $770,995 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective February 2, 2026, through November 30, 2029. The research initiative investigates the role of intestinal epithelial heat shock protein 25/27 (HSP25/27) in mucosal healing and restitution following inflammatory...
- Federal Grant Award Summary Northwestern University received a $731,850 Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), awarded September 5, 2025, with a completion date of May 31, 2029. The research project, titled "Bioenergetics of Time-Restricted Feeding Within the Brain-Adipose Axis," will advance fundamental scientific understanding of how...
- Federal Grant Award Summary Albert Einstein College of Medicine received a $560,100 Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), awarded on September 11, 2025, with a completion date of June 30, 2030. The research project investigates the role of environmental exposure and inflammation on hematopoietic stem cell (HSC) disorders, with particular focus on...
- Federal Grant Award Summary The University of Chicago received a $151,040 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective December 11, 2025, through November 30, 2028. This research project will establish the zebrafish pronephros (embryonic kidney) as an in vivo model system to investigate how epithelial cell collectives sense and respond...
- Federal Grant Award Summary Northwestern University's Sponsored Research Division received a $748,965 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective September 1, 2025, with completion targeted for May 31, 2029. The research will be performed at the university's Chicago, Illinois facility. This award supports investigative research aimed at understanding vascular proliferative...
- Federal Grant Award Summary Albert Einstein College of Medicine received a $829,319 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective February 1, 2026, through November 30, 2030. The award funds research to identify collaborating factors driving DDX41 (ATPASE dead-box helicase 41) mutant pathology in myelodysplastic syndromes (MDS), a bone...
- Federal Project Grant Award Summary Cleveland State University received a $552,763 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) on February 15, 2026, with a completion date of January 31, 2029. The award supports investigator-initiated basic biomedical research aimed at understanding the molecular mechanisms governing transcriptional responses...
- Federal Grant Award Summary Baylor College of Medicine received a $200,000 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective September 15, 2025 through August 31, 2026. The project, titled "Structural Proteome Diversity as a Determinant of Hematopoietic Aging," delivers integrated research services focused on understanding how...
Northwestern University's Sponsored Research Division received a $679,530 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective March 15, 2026, with a completion date of January 31, 2030. The research project, conducted at the Chicago, Illinois location, investigates the anatomy, composition, and functions of erythroblastic islands (EBIs)—specialized niches comprising macrophages and developing erythroid cells essential for red blood cell terminal differentiation—in both mice and humans during physiologic and stress conditions using spatial mapping technologies and transcriptomic analysis. The deliverables encompass foundational research outputs including spatial transcriptomic studies characterizing the composition and organization of EBIs across multiple contexts, comparative analysis revealing species-specific differences between murine and human erythroid niches, identification of critical molecular markers such as ICAM4 (intercellular adhesion molecule 4) that mediate erythroid-centered niche formation, and validation studies using human induced pluripotent stem cell-derived bone marrow organoid models. These research activities advance understanding of erythroid cell development mechanisms and contribute to the NIDDK's broader mission of improving knowledge regarding hematologic diseases and related metabolic disorders.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $679.5k | 3/13/26 |