Project Grant R01DK142725
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), awarded a $224,088 Project Grant to the Regents of the University of Michigan (University of Michigan) to conduct research aimed at elucidating the mechanisms of Notch signaling in immature and adult intestinal stem cells. The research will investigate how intestinal stem cells maintain Notch signaling and regulate stem cell...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $497,370 Project Grant (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) to the Regents of the University of Michigan. The grant, titled "CD45 MEDIATED REGULATION OF PMN FUNCTION DURING INTESTINAL INFLAMMATION", will fund research to determine the effects of neutrophil-specific loss of the CD45 tyrosine phosphatase on intestinal inflammation and repair processes. The...
- This federal Project Grant award of $580,568, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research on the role of the CD45 tyrosine phosphatase in regulating neutrophil function and intestinal inflammation. The research aims to elucidate the effects of neutrophil-specific loss of CD45 on intestinal inflammation and repair, as well as how CD45...
- This Project Grant award, totaling $502,233, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research conducted by the Regents of the University of Michigan to investigate neuron populations in the nucleus of the solitary tract (NTS) that mediate the aversive and non-aversive suppression of food intake. The research aims to further...
- This federal Project Grant award for $836,942 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research into the role of autophagy (self-digestion) in intestinal regeneration and stem cell activity. The research aims to investigate how autophagy contributes to injury resistance and the ability of certain intestinal cell types to re-acquire stem cell-like...
- This federal Project Grant award of $465,444.00, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to investigate how commensal fungi in the gut can promote intestinal wound repair. The research aims to mechanistically understand how fungi modulate epithelial cells and fibroblasts to enhance crypt regeneration, with a focus on identifying the...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), through the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), awarded a $133,333 Project Grant to Yale University to study the mechanisms underlying the myeloid bias in aged hematopoietic stem and progenitor cells (HSPCs). The research aims to correct this myeloid bias by preventing the turnover of the linker histone H1.0, which could have implications for addressing diverse...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), part of the National Institutes of Health, awarded a $728,801 Project Grant to the Regents of the University of Michigan under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant funds a 5-year project to test a novel weight navigation program aimed at overcoming barriers to obesity treatment in primary care settings. The project seeks to improve utilization of effective...
- This Project Grant award, in the amount of $126,846, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports a translational research project to investigate the role of the gut microbiome in the pathogenesis of sepsis-associated acute kidney injury (AKI). The research, to be conducted at the University of Michigan, aims to identify gut bacteria...
- This $2,557,146 Project Grant award was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award was made to the Board of Regents of the Nevada System of Higher Education (UEI: WLDGTNCFFJZ3), operating through the University of Nevada, Reno, and will fund research to explore novel targets for gastrointestinal hormones and neuropeptides in the regulation of...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $611,447 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to the Regents of the University of Michigan. The project aims to define a novel signaling axis regulating gastric epithelial cell homeostasis and response to injury. Specifically, the research will investigate how Wnt signaling activates retinoic acid signaling to maintain gastric epithelial cell function and regulate chief cell remodeling after injury. The project will utilize in vivo mouse models and in vitro organoid models to measure gastric stem cell and chief cell (reserve stem cell) function during homeostasis and after induced injury. The award period is from September 1, 2025 through June 30, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $611.4k | 8/21/25 |