Project Grant R01DK142027
- This $128,286 Project Grant award, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will support research into the mechanisms of renal lipotoxicity and its contribution to the development of chronic kidney disease (CKD). The principal investigator will investigate the protective role of the FAF2 gene knockout in mitigating palmitate-induced lipotoxicity in...
- This federal Project Grant award, in the amount of $531,999.00, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award is supporting research focused on understanding the role of alternative splicing in the proximal tubules of the kidney and its relationship to the progression of diabetic kidney disease. The research will investigate how diabetes...
- This federal Project Grant award, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to investigate the molecular mechanisms driving the transition from acute kidney injury (AKI) to chronic kidney disease (CKD). The $1,491,303 award to The Washington University aims to characterize how the repression of the FOXM1-CCNF axis during tubular epithelial...
- This $148,986 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) is funding research to investigate the role of BKγ subunits in regulating potassium secretion in the distal nephron. The research aims to improve understanding of the mechanisms underlying flow-induced potassium secretion, which is critical for maintaining whole-body potassium...
- This Project Grant award of $404,883 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to develop integrated spatial transcriptomics and proteomics technologies for studying kidney disease. The project, titled "Submicron-Resolution Integrated Spatial Transcriptomics and Proteomics for Studying Kidney Disease", will optimize a high-resolution spatial...
- This Project Grant award of $830,500.00 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research program) supports research investigating the role of glycosphingolipids in kidney disease associated with diabetes and obesity. The key objectives are to: Test whether inhibiting glucosylceramide synthesis in podocytes, renal tubules, or the immune system can prevent progression of kidney disease in mouse...
- This federal Project Grant award of $176,244 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) to the University of California, San Francisco supports a 5-year research and training plan focused on the mechanisms underlying ciliary kidney diseases. The grant recipient, Dr. Gabriel Loeb, will investigate whether the transcription factor GLIS3 is regulated by the polycystin proteins and acts downstream of them to prevent kidney cyst formation. This work aims...
- This federal Project Grant award of $342,002.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The funding supports research at Western Michigan University Homer Stryker M.D. School of Medicine (WMED) to develop novel cellular tools for studying the regulation of the PKD1 gene in autosomal dominant polycystic kidney disease (ADPKD). The research aims to...
- This $596,345 federal Project Grant was awarded on May 1, 2025 by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research conducted by the Augusta University Research Institute, Inc. in Augusta, GA to investigate the molecular mechanisms underlying diabetic renal hypertrophy and its impact on acute kidney injury (AKI) susceptibility in diabetic...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $659,182 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to Rhode Island Hospital, a division of Lifespan Corporation. The funding will support research to elucidate the role and mechanism of histone deacetylase 6 (HDAC6) in cisplatin-induced kidney injury, fibrosis, and chronic kidney disease, and to identify HDAC6 inhibition as a novel approach for...
This federal Project Grant award of $710,728 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research program) supports research by Oregon Health & Science University to define cell states in the kidney along the thick ascending limb, distal convoluted tubule, and connecting tubule. The research aims to characterize cell types in these regions, determine how potassium stress, diuretic drugs, water stress, and calcium stress affect cell state, and develop new physiological models. The award period runs from September 1, 2025 to June 30, 2030 and the research is expected to improve understanding of kidney function and inform new approaches for managing kidney-related diseases.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $710.7k | 8/28/25 |