Project Grant R01DK141923

Award Date 9/20/24
Completion Date 7/31/29
Dollars Obligated $643K
Federal Grant Program
93.847
Assistance Type
Project Grant
Place of Performance
Boston, MA 02215, USA
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This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $642,653 to the Trustees of Boston University to develop a novel treatment called "Lysogen" for metabolic dysfunction-associated steatotic liver disease (MASLD). The key products and services to be delivered include:

  1. Synthesizing and characterizing Lysogen polymers that activate at a pH of 6 and are targeted to lysosomes.
  2. Determining the in vitro bioavailability and bioactivity of the Lysogen treatment.
  3. Evaluating the toxicity, biodistribution, and efficacy of the optimized Lysogen formulation in a high-fat diet-induced MASLD mouse model.

The award period runs from September 20, 2024 to July 31, 2029, aiming to advance this first-of-its-kind Lysogen technology as a potential treatment for MASLD, a liver disease associated with metabolic dysfunction and aging.

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