Project Grant R01DK141823
- This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will support research to elucidate the functional roles of non-coding genetic variants associated with metabolic dysfunction-associated steatotic liver disease (MASLD). The $146,570 award, with a project period from January 1, 2025 to November 30, 2029, will be provided to The Trustees of the...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $2,999,512 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to The University of Texas Southwestern Medical Center, doing business as Southwestern Medical School. This 4-year award, starting on September 1, 2025, will support research to investigate the regulation of mitochondrial health in mammalian livers, with a focus on understanding the...
- This Project Grant award of $1,982,628.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research to develop advanced methods for detecting liver fibrosis and creating a predictive diagnostic model for Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) in primary care settings. The project aims to improve identification of...
- This federal Project Grant award of $544,963, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to investigate the role of the protein frataxin (FXN) in metabolic dysfunction-associated steatotic liver disease (MASLD). The research conducted under this award will examine whether FXN deficiency induces and whether restoration of FXN expression prevents...
- This $824,655 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research aimed at understanding the role of sex-biased transcription factors in conferring protection against metabolic dysfunction-associated steatotic liver disease (MASLD) in females. The research will use adult-onset, hepatocyte-specific knockdown technology to elucidate...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $773,112 Project Grant to Rockefeller University on September 5, 2025 under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research to investigate the mechanisms of transcriptional control in adipocyte formation and function through nuclear receptor coactivators. The research aims to provide a better understanding of dysregulation in energy storage...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), part of the National Institutes of Health, awarded a $728,801 Project Grant to the Regents of the University of Michigan under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant funds a 5-year project to test a novel weight navigation program aimed at overcoming barriers to obesity treatment in primary care settings. The project seeks to improve utilization of effective...
- This $882,180 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will support a comprehensive research effort to analyze the largest dataset of rare genetic variants associated with diabetes. The Broad Institute, Inc. will lead this project to assess variant penetrance and integrate the genomic data with high-throughput cellular assays to...
- This federal Project Grant award of $122,454, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research investigating the role of the GIMAP5 gene in maintaining liver homeostasis. The primary recipient, Yale University, is conducting studies to determine how loss of function in the GIMAP5 gene leads to capillarization and dedifferentiation of liver...
- This $786,216 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research on post-transcriptional regulation of hepatokines and their impact on systemic metabolism. The University of California, Los Angeles is conducting this research to investigate a novel mechanism by which the liver uses RNA-binding proteins to control the...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $776,863 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to the Regents of the University of Michigan. The award will fund a multi-ancestry whole genome sequencing analysis of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), a globally prevalent condition caused by excess fat accumulation in the liver. The research aims to uncover genetic factors that influence MASLD across diverse ancestries and validate the identified genetic variants through functional follow-up studies in liver cell lines. The project will leverage advanced imaging techniques and large population-based cohorts to comprehensively examine the genetic underpinnings of this common chronic liver disease, with the goal of informing new prevention and treatment approaches.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $776.9k | 9/11/25 |