Project Grant R01DK141800
- The National Institute of Neurological Disorders and Stroke awarded $422,125 to the University of Miami on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to conduct a randomized, waitlist-controlled mechanistic trial characterizing how auricular vagus nerve stimulation modulates HIV-associated peripheral neuropathy in aging adults. The study enrolls 70 adults aged 50 and older with chronic HIV-associated...
- The National Institute of Neurological Disorders and Stroke awarded the University of Rochester $2,197,287 on August 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct a Phase III confirmatory clinical trial of daily, wireless, home-based transcutaneous electrical nerve stimulation (TENS) for chemotherapy-induced peripheral neuropathy (CIPN). The trial will evaluate TENS efficacy in relieving neuropathic pain in cancer patients who have developed CIPN—a common...
- The National Institute of Neurological Disorders and Stroke, a component of the Department of Health and Human Services National Institutes of Health, awarded the University of Florida $603,019 on July 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to optimize novel REV-ERB agonist compounds for treatment of chronic inflammatory pain. The funded research develops high-affinity REV-ERB agonists with demonstrated in vivo...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $3,565,780 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to develop a groundbreaking high-frequency trans-spinal magnetic stimulation (HF-TSMS) system for the non-invasive treatment of neuropathic pain. The funded project aims to create an HF-TSMS tool that can target neural pathways involved in...
- The National Institute of Neurological Disorders and Stroke awarded Case Western Reserve University $3,778,614 on August 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to develop and validate transient selective neural inhibition via photobiomodulation (TSNIP) for chronic knee pain treatment. The research integrates optimized TSNIP parameters into the COSMIIC modular platform—an FDA-qualified system already proven safe for electrical stimulation and sensing in...
- The National Institute of Neurological Disorders and Stroke awarded the Regents of the University of Minnesota a cooperative agreement valued at $769,903 on August 1, 2026, to conduct a feasibility and pilot trial of a novel invasive brain stimulation approach for chronic neuropathic pain. The study combines precision functional mapping and individualized neurostimulation targeting the somato-cognitive action network and cingulo-opercular network—two key circuits in pain processing—to address...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded The Johns Hopkins University $1,591,234 on September 10, 2025, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to conduct clinical research on wearable interactive sensory insoles for prevention of recurrent diabetic foot ulcers. The research investigates whether interactive sensory insoles manufactured by Orpyx Medical Technologies can reduce recurrence of diabetic foot...
- The National Institute of Neurological Disorders and Stroke awarded the University of Colorado-Denver $723,065 on August 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to conduct a pilot clinical investigation of transcutaneous auricular vagus nerve stimulation paired with motor learning in patients with multiple sclerosis. The research explores whether closed-loop, non-invasive vagus nerve stimulation can enhance myelin...
- The National Institute of Neurological Disorders and Stroke awarded The University of Chicago $677,636 on August 15, 2026, to develop programmable lithium-ion delivery devices for motor-sparing neuropathic pain therapy under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The project introduces a lithium-delivering bioelectronic platform with AI-enabled closed-loop control that provides programmable, localized, and reversible conduction...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded $150,342 to the University of Washington on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds investigation of how long-term, closed-loop, epidural spinal cord stimulation affects neuropathic pain symptoms in rats with cervical spinal cord injury. The...
The National Institute of Neurological Disorders and Stroke awarded the University of Florida $1,497,985 on September 3, 2026, to conduct a randomized clinical trial evaluating wearable focal vibration therapy for diabetic peripheral neuropathy under CFDA 93.279 (Drug Use and Addiction Research Programs). The research will enroll 120 participants with diabetic peripheral neuropathy in an eight-week trial comparing four weeks of wearable focal vibration therapy against sham vibration control. The trial measures treatment effects on functional mobility and pain at treatment completion and four weeks after therapy ends, and explores pain phenotypes and mediators of treatment response. Participants are randomly assigned to either standard care plus education with wearable focal vibration (MyoVolt technology developed by the principal investigator) or standard care plus education with sham vibration. The wearable device delivers vibration therapy to three target muscles via face-to-face instruction and at-home prescription protocols. Performance occurs in Gainesville, Florida, with work extending through August 31, 2029. The University of Florida Division of Sponsored Research administers the award as prime recipient.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.5m | 9/3/26 |