Project Grant R01DK141602

Award Date 12/15/24
Completion Date 11/30/28
Dollars Obligated $726K
Federal Grant Program
93.847
Assistance Type
Project Grant
Place of Performance
Philadelphia, PA 19104, USA
Similar Awards
This Project Grant award, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), is intended to support research to identify somatic genetic mutations that may ameliorate chronic liver disease progression. The $754,400 award to the University of Texas Southwestern Medical Center will fund research to uncover adaptive genetic pathways specific to different liver...
This federal Project Grant award, valued at $146,570, was issued by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award supports research to elucidate the cis-regulatory function of genetic variants associated with metabolic dysfunction-associated steatotic liver disease (MASLD) in a cell-type-specific manner using iPSC-derived liver cells and organoids. The...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $683,339 to the University of Pittsburgh to conduct research on cell competition and fitness for combating chronic liver diseases. The key objectives are to uncover the mechanism of cell competition in the liver, investigate the liver repair efficacy of competing human...
This $544,458 Project Grant award was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The primary goal of the research project is to investigate the mechanisms by which the XBP1 pathway regulates bile acid metabolism during cholestatic liver diseases. The research will be conducted by Northwestern University and aims to identify new molecular targets for...
This $689,050 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to investigate the mechanisms of epithelial-mesenchymal crosstalk in intrahepatic biliary formation. The research, conducted by Weill Medical College of Cornell University, seeks to define the roles of Gli1-expressing periportal mesenchyme and epithelial Ihh in regulating...
This $172,060 Project Grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research program) supports research to understand the role of the unfolded protein response (UPR) in the development of non-alcoholic steatohepatitis (NASH), a leading cause of liver disease. The primary awardee, The General Hospital Corporation (Massachusetts General Hospital), will conduct studies using human liver...
This is a Project Grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The $748,418 award will fund research investigating the role of hepatic endoplasmic reticulum (ER) architecture in regulating metabolic homeostasis and its potential contribution to metabolic dysfunction associated fatty liver disease (MAFLD). The primary objectives are to: 1) delineate the...
This Project Grant award, valued at $147,656.00, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The funding supports research to advance understanding of the mechanisms by which fetal growth restriction leads to increased risk of liver fibrosis and metabolic disease in offspring. Key objectives include: 1) identifying cell-specific and regional gene...
This federal Project Grant award for $506,546.00, granted by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to define the molecular determinants of inflammatory memory in the pancreas. The award, effective July 1, 2024 through May 31, 2029, is provided to Weill Medical College of Cornell University to leverage lineage-traced mouse models to: 1)...
This $609,191 Project Grant award was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant is funding a study at Duke University to comprehensively investigate the role of genomic imprinting and epigenetic modifications in the development of non-alcoholic fatty liver disease (NAFLD) in a diverse cohort of 500 adolescents. Key objectives include...

This R01 Project Grant award, totaling $726,019, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award will fund research conducted by the Zaret Lab at the University of Pennsylvania and the Mir Lab at Children's Hospital of Philadelphia to investigate how changes in transcription factor and heterochromatin states in embryos and adult livers impact hepatocyte development, homeostasis, and regeneration. The researchers will use advanced in vivo imaging technologies and genetic perturbations to elucidate the molecular interactions driving cell fate specification and zonal heterogeneity in the liver. This work aims to provide novel insights into liver development and regeneration that could inform new approaches for generating hepatic cells from pluripotent cells and improve understanding of other gut-derived tissues. The award period runs from December 15, 2024 to November 30, 2028.

Generated 4/8/25, 5:24 AM