This federal Project Grant award, with ID R03DK141827, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The $116,625 award, granted on March 12, 2025, supports research conducted by the University of Iowa to investigate the epithelial-specific roles of the antioxidant protein glutathione peroxidase 1 (GPX1) in intestinal homeostasis, stem cell biology, and experimental colitis. This research aims to provide clarity on the contributions of GPX1 to intestinal health and inflammatory bowel disease pathobiology, with the potential to advance therapeutic options. The study leverages a novel GPX1 floxed mouse model developed by the University of Iowa to enable cell type-specific investigations. The award will fund research activities at the University of Iowa's facilities in Iowa City, IA through the ultimate completion date of February 28, 2027.
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