This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under CFDA Program 93.855 Allergy and Infectious Diseases Research, is focused on understanding the mechanisms by which the human immune system naturally restricts a specific subset of HIV known as X4-tropic virus. The $197,366 award, effective from March 1, 2025 to February 28, 2030, will support research at Washington University to (1) characterize the molecular mechanisms driving restriction of...
This Project Grant award of $829,985.00 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research supports research to develop new Drosophila, mouse, and human podocyte models to study the interactions between HIV and APOL1-G1 risk alleles that contribute to the development of HIV-associated chronic kidney diseases (HIV-CKD). The research aims to define the mechanisms by which APOL1-G1...
This $926,057 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under CFDA 93.855 Allergy and Infectious Diseases Research is supporting research to understand how the gut microbiota influences immune responses, particularly B-cell development and antibody production, following vaccination. The project aims to identify gut stromal cell populations and microbial components that are crucial for enhancing stromal cell function and promoting improved...
This Project Grant award of $1,454,386.00 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports fundamental research to better understand the epigenetic regulation of the HIV-1 viral RNA cap. The research aims to define the structural basis of HIV cap hypermethylation and its linkage to modulating host innate immune signaling, with the goal of developing new treatments to neutralize deleterious...
This Project Grant award of $186,451.00 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to characterize the molecular mechanism of CD4+ T cell migration to the brain during HIV/AIDS-associated cryptococcal immune reconstitution inflammatory syndrome (IRIS). The primary goals are to determine whether TNF-α signaling and CD11a expression mediate CD4+ T cell migration to the brain in...
This $775,391 federal Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) aims to investigate the role of the human protein galectin-9 in HIV persistence and the establishment of the long-term viral reservoir. The primary awardee, Vitalant Research Institute, will conduct in vitro studies to elucidate the molecular and immunological mechanisms underlying galectin-9's impact on the HIV reservoir. Additionally,...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $516,648 to The Leland Stanford Junior University to conduct research on understanding the mechanisms by which microbially derived metabolites regulate host gut inflammation. The award period runs from August 28, 2024 to February 28, 2027. The research aims to determine the regulatory...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $220,224 to the University of Chicago to computationally investigate key morphological transitions in the HIV-1 life cycle. The research aims to gain a deeper mechanistic understanding of HIV assembly, maturation, and uncoating processes, with a focus on the roles of viral RNA, host cell factors, and...
This federal Project Grant award, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to elucidate the molecular mechanisms underlying T cell dysfunction and HIV persistence in persons with HIV (PWH). The $500,000 award, effective from September 1, 2024 to August 31, 2029, will support research conducted by The General Hospital Corporation (Massachusetts General Hospital) to identify and...
This Project Grant award from the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) provides $533,750.00 to the University of Florida to study the role of macrophages in the increased HIV risk associated with bacterial vaginosis (BV). The research aims to determine how a non-optimal vaginal microbiome affects the activation and "training" of macrophages towards an HIV-permissive phenotype. This will be...