The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $235,403 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to The Johns Hopkins University. The funding will support the development of a membrane-reconstituted ZNT8 biosensor to detect cell-surface ZNT8 autoantibodies in the peripheral blood of patients with type-1 diabetes. This novel bioanalytical tool aims to enable the early detection of islet...
This $1,592,670 Project Grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) will fund research at the University of Massachusetts Medical School (UMMS) to study the influence of MHC-II polymorphisms on autoimmune T cell repertoire development and function in type 1 diabetes (T1D). The research aims to identify tissue- and disease-specific processes underlying T1D...
This $1,080,680 Cooperative Agreement, awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to investigate the role of specific T cell populations and clones in the increased risk of cardiovascular disease (CVD) caused by atherosclerosis in individuals with type 1 diabetes (T1D). The project aims to leverage the unique resources of the CARE-T1D...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded Brigham Young University a $568,075 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research to determine the role of the NR4A1 protein in regulating the GLP-1R and DYRK1A pathways, which are critical for expanding functional beta-cell mass as a potential treatment for type 1 and type 2 diabetes. The research aims to elucidate the...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will support research to investigate the mechanisms underlying the development of type 1 diabetes (T1D). The $3,227,113 award, granted to The Trustees of the University of Pennsylvania, will enable the research team to define the cross-reactivity between microbial and self-antigens in T1D patients...
This federal Project Grant award, R01DK140781, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The $1,449,016 award aims to use advanced immunoproteomics technologies to comprehensively screen for microbial infections associated with increased or decreased risk of islet autoimmunity and type 1 diabetes in children participating in the TEDDY study. The project...
This federal Cooperative Agreement award, funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $1,201,988 to Yale University to develop and validate advanced pancreatic-immune organoid models. The goal is to characterize B cell intrinsic features that determine the progression of type 1 diabetes (T1D) and responses to immunotherapies. The award will support the...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $1,338,684 to Yale University to conduct a longitudinal study utilizing PET and MRI techniques. The goal is to assess insulin vesicle functional capacity, beta cell mass, and pancreas volume in individuals at risk for and with recent onset type 1 diabetes. The study aims to...
This Cooperative Agreement award of $1,232,846.00 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports the development of a vascularized micro-organ platform to study the mechanisms of beta cell death in type 1 diabetes. The key objectives are to: 1) Build a histocompatible system using induced pluripotent stem cells (iPSCs) from type 1 diabetes patients and...
This Cooperative Agreement award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $962,975 to study the molecular and cellular mechanisms underlying the increased cardiovascular disease (CVD) risk in individuals with type 1 diabetes (T1D) compared to type 2 diabetes (T2D) and non-diabetic individuals. The 3-year project, starting on September 18, 2024, aims...