This $755,970 Project Grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research to address key challenges in the care of patients who develop immune checkpoint inhibitor-associated acute interstitial nephritis (ICI-AIN). The goals are to: Test the use of the biomarker CXCL9 to accurately diagnose ICI-AIN and predict response to corticosteroid therapy. This will be evaluated across 400 participants who develop acute kidney injury while on immune checkpoint inhibitor therapy, with an expected 100 cases of ICI-AIN. Compare urine and plasma proteomic profiles between steroid-refractory and steroid-sensitive ICI-AIN to identify dysregulated pathways that could guide selection of second-line immunosuppressive therapies. The research will be conducted by a multidisciplinary team at Yale University, Massachusetts General Hospital, and Johns Hopkins University over the award period from August 2024 to June 2028. The goal is to develop improved diagnostics and insights to enhance treatment of this adverse effect associated with a revolutionary cancer therapy.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $756.0k | 8/8/24 |