Project Grant R01DK140717

Award Date 8/10/24
Completion Date 6/30/28
Dollars Obligated $756K
Federal Grant Program
93.847
Assistance Type
Project Grant
Place of Performance
Connecticut, USA
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This Project Grant award from the National Cancer Institute (CFDA 93.398 Cancer Research Manpower) provides $124,134 to Yale University to conduct research investigating the mechanisms underlying immune-related adverse events (IRAEs), specifically immune checkpoint inhibitor (ICI)-induced colitis, and to evaluate targeted therapies for mitigating colitis. The research aims to define the key T cell subsets and trafficking mechanisms driving colon inflammation in ICI-colitis, as well as to...
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This $755,970 Project Grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research to address key challenges in the care of patients who develop immune checkpoint inhibitor-associated acute interstitial nephritis (ICI-AIN). The goals are to:

  1. Test the use of the biomarker CXCL9 to accurately diagnose ICI-AIN and predict response to corticosteroid therapy. This will be evaluated across 400 participants who develop acute kidney injury while on immune checkpoint inhibitor therapy, with an expected 100 cases of ICI-AIN.

  2. Compare urine and plasma proteomic profiles between steroid-refractory and steroid-sensitive ICI-AIN to identify dysregulated pathways that could guide selection of second-line immunosuppressive therapies.

The research will be conducted by a multidisciplinary team at Yale University, Massachusetts General Hospital, and Johns Hopkins University over the award period from August 2024 to June 2028. The goal is to develop improved diagnostics and insights to enhance treatment of this adverse effect associated with a revolutionary cancer therapy.

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