Project Grant R01DK140714
- This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) totals $167,768 and aims to evaluate whether beta-lactam antibiotics increase the risk of acute kidney injury (AKI) in patients receiving immune checkpoint inhibitor (ICI) cancer treatments, compared to fluoroquinolone antibiotics. The award will support a target trial emulation study to assess this...
- This $2,833,514 Project Grant was awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant, titled "Renal Metabolism in AKI", will fund research to investigate changes in kidney metabolism in sepsis-associated acute kidney injury (AKI) and their impact on kidney tubule injury and recovery. The University of California, San Diego (UCSD) is the awardee...
- This $171,639 Project Grant award was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award supports a "Multi-omic Investigation of Uremic Toxin Sources and Accumulation in Children with Kidney Failure" conducted by the Children's Hospital of Philadelphia (CHOP). The key objectives of this research project are to: 1) Characterize the contributions...
- This $809,427 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research on the impact of polymicrobial interactions and within-host adaptation on the pathogenesis of catheter-associated urinary tract infections (CAUTI). The award recipient, The Research Foundation For The State University Of New York (RF SUNY) doing business as Sponsored...
- This Project Grant award, in the amount of $126,846, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports a translational research project to investigate the role of the gut microbiome in the pathogenesis of sepsis-associated acute kidney injury (AKI). The research, to be conducted at the University of Michigan, aims to identify gut bacteria...
- This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $199,999 to the University of Florida to develop innovative artificial intelligence (AI)-based methods to support the discovery of potent, orally available small-molecule heparanase inhibitors. The goal is to evaluate these novel heparanase inhibitors in murine models as a...
- This federal Project Grant award of $3,010,432 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), is funding research to develop mitoprotective therapies for the treatment of acute kidney injury (AKI). The key objectives of this research are to characterize a novel mitochondrial protein target, phospholipid scramblase 3 (PLSCR3), and evaluate pharmacological activators...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), through the Diabetes, Digestive, and Kidney Diseases Extramural Research Program (CFDA 93.847), awarded a $671,986 Project Grant to Rutgers, The State University of New Jersey, to conduct research aimed at strengthening the evidence-base for medication prescribing in older adults with chronic kidney disease (CKD). The key objectives of the 4-year project are to: 1) evaluate the effectiveness of renoprotective therapies...
- This $427,625 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to understand the causes of treatment failure for hypervirulent Klebsiella pneumoniae liver abscesses. The research aims to visualize antibiotic distribution and the role of antibiotic-tolerant bacterial cells in this treatment failure, as well as examine the transcriptional profile of the bacteria in...
- This $128,286 Project Grant award, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will support research into the mechanisms of renal lipotoxicity and its contribution to the development of chronic kidney disease (CKD). The principal investigator will investigate the protective role of the FAF2 gene knockout in mitigating palmitate-induced lipotoxicity in...
This $804,993 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports a clinical trial at the University of Pennsylvania to investigate "Markers of Nephrotoxicity During Treatment with Antibiotic Combinations." The project aims to evaluate whether the combined use of vancomycin and piperacillin-tazobactam antibiotics is truly nephrotoxic, as indicated by standard creatinine-based biomarkers, or if it represents "pseudotoxicity" from the antibiotics' impact on creatinine secretion without actual kidney injury. The award, with a project period from September 9, 2025 to May 31, 2030, will support this clinical research to improve understanding of antibiotic-associated acute kidney injury.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $805.0k | 9/3/25 |