Project Grant R01DK140672
- This federal Project Grant award of $140,116 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research conducted by the Beckman Research Institute of the City of Hope to identify and characterize a new mechanism of communication between the intestine and white adipose tissue (WAT) that regulates glucose homeostasis and energy metabolism. The...
- This Project Grant award of $400,000 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to explore the role of insulin resistance in the development of renal disease during prepubertal childhood obesity. The research aims to investigate how insulin resistance alters glucose transport and energy metabolism in renal proximal tubules, potentially leading to...
- The federal Project Grant award of $168,900 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research to determine how the commensal bacterium Blautia activates signaling in gut epithelial cells to benefit host metabolism and mucosal health. The overall objective is to delineate the mechanisms by which Blautia and its metabolites, particularly acyl amines,...
- The University of Colorado-Denver received a $129,619 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) on September 1, 2025. The goal of this 5-year research project is to investigate the interactions between the gut microbiome, intestinal development, and metabolic health in an animal model of fetal growth restriction (FGR). The researchers will assess the function of...
- This federal Project Grant award of $107,250, awarded on April 1, 2025 by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to investigate the role of the nuclear receptor NR2F2 in regulating beige adipogenesis and preventing later-life obesity. The research, conducted by the University of Oklahoma Health Sciences Center, aims to understand how...
- This $695,295 federal Project Grant award was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research to investigate the developmental trajectories of reinforcer pathology and childhood obesity, examining how changes in food and physical activity reinforcement as well as delay discounting may contribute to the increase in obesity from...
- This federal Project Grant award of $3,103,125 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research to understand the role of lipogenic pathways in intestinal remodeling after Roux-en-Y gastric bypass surgery. The primary awardee, The Children's Hospital Corporation (doing business as Boston Children's Hospital), will conduct experiments to test the hypothesis that changes in...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded Duke University a $241,500 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to study the regulation of metabolic diseases by the human commensal bacterium Clostridium immunis. The overarching goal is to determine the mechanism by which an exopolysaccharide (EPS) secreted by C. immunis decreases visceral adiposity, a key risk factor for type 2 diabetes and...
- This $1,074,199 Project Grant award, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will fund research conducted by the Albert Einstein College of Medicine in Bronx, NY. The project aims to investigate the role of melanocortin-based neural circuits linking the hypothalamus and medial prefrontal cortex in regulating feeding behavior and obesity. Specifically, the...
- This federal Project Grant award, valued at $147,486 and provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under CFDA 93.847 "Diabetes, Digestive, and Kidney Diseases Extramural Research", will support research to comprehensively establish the role of gut microbes in modulating pancreatic interleukin-22 (IL-22) and the consequences of this gut-to-pancreas axis on pancreatic health and disease. The research project, to be conducted at the...
This federal Project Grant award of $802,843 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research conducted by Yale University to understand the relationship between intestinal microbial activity and human metabolism, particularly in pediatric obesity and insulin resistance. The research aims to investigate: 1) how insulin resistance affects the adipose tissue lipolysis response to intestinal fermentation, 2) whether changes in adipose tissue lipolysis are associated with reduced glycerol-derived gluconeogenesis, and 3) if physical activity can restore the entero-endocrine and adipose tissue response to intestinal fermentation in youth with insulin resistance. The project seeks to provide novel insights into the pathogenic mechanisms underlying the development of cardiometabolic complications in pediatric obesity. The award period runs from September 2025 through June 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $802.8k | 9/13/25 |