This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) provides $806,192 to support research on the role of the MRP9 protein in cholangiocyte (bile duct cell) metabolism. The research aims to elucidate how MRP9 deficiency leads to cholangiocyte injury and cell death, which can contribute to cholestatic cholangiopathies - liver disorders affecting the bile ducts. The...
This federal Project Grant award of $692,243 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research program, aims to explore the role of the hepatic lymphatic system in cholestatic liver diseases. The key objectives are to: 1) Determine the role of the hepatic lymphatic system in cholestatic liver disease, 2) Elucidate the mechanism of bile acid-driven hepatic lymphangiogenesis, and...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research) provides $1,170,271 to Northwestern University to investigate the role of the X-box binding protein 1 (XBP1) signaling pathway in regulating bile acid metabolism during cholestatic liver disease. The central hypothesis is that XBP1 activation transcriptionally modulates key bile acid metabolic genes like CYP7A1 and SHP to...
This Project Grant award of $1,637,916 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research to investigate the role of neutrophil extracellular traps (NETs) in biliary fibrosis associated with biliary atresia. The research, conducted by the Medical College of Wisconsin, Inc., aims to elucidate the mechanisms of NET formation mediated by the CXCL8-CXCR2 pathway and assess the...
This federal Project Grant award of $675,660.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award was granted to the Beth Israel Deaconess Medical Center, Inc. (Bidmc) to conduct research focused on understanding the regulation and requirements for coenzyme A (CoA) biosynthesis, and how dysregulation of CoA synthesis is related to metabolic diseases...
The U.S. National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $222,500 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to the Beckman Research Institute of the City of Hope. The grant supports research to understand how conjugated bile acids regulate metabolism after bariatric surgery, with the goal of developing safer and more affordable treatments for obesity and fatty liver disease. Key activities include...
This federal Project Grant award of $637,000.00 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research to explore the production and signaling properties of novel bile acids produced by the gut microbiome. The project aims to 1) define the microbiology of microbially conjugated bile acid (MCBA) production, 2) determine the agonist activity of MCBAs on the...
This $754,400 Project Grant award was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research (CFDA 93.847) program. The funding will support research by The University of Texas Southwestern Medical Center (UT Southwestern) to identify adaptive genetic pathways and understand how mutant clones expand within chronically damaged liver tissues, with the goal of developing therapeutic approaches...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $561,785 to Virginia Commonwealth University (VCU) to investigate the role of circular RNAs (circRNAs) in the progression of cholestatic liver diseases, particularly primary sclerosing cholangitis (PSC). The research aims to 1) examine how H19-induced upregulation of specific...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) is funding research to develop a therapeutic approach using dicarboxylic acids (DCAs) to prevent and treat acute kidney injury (AKI) and limit progression to chronic kidney disease (CKD). The $645,599 award to the University of Pittsburgh is supporting preclinical studies in animal models...