Project Grant R01DK139672

Award Date 9/19/24
Completion Date 5/31/29
Dollars Obligated $2.2M
Federal Grant Program
93.847
Assistance Type
Project Grant
Place of Performance
Hamden, CT 06511, USA
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This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports a research project titled "CREBRF and Risk of Pregnancy and Postpartum Dysglycemia in American Samoan Women." The $2,190,352 grant, awarded on Sep 19, 2024, will fund a prospective cohort study of 350 pregnant American Samoan women to investigate the impact of a genetic variant in the CREBRF gene on the risk of gestational diabetes (GDM) and postpartum type 2 diabetes.

The key products and services to be delivered under this grant include: 1) comprehensive evaluation of glucose homeostasis and insulin response throughout pregnancy and postpartum via oral glucose tolerance tests, HbA1c, and continuous glucose monitoring; 2) statistical analysis to examine associations between the CREBRF variant, glucose homeostasis, insulin secretion, and risk of GDM and postpartum pre-diabetes/type 2 diabetes; and 3) exploration of the connections between the CREBRF variant, insulin secretion, and birth outcomes. The project aims to provide insights into the potential of the CREBRF variant as a genetic biomarker for GDM and type 2 diabetes risk, as well as uncover the underlying mechanisms by which this variant regulates glucose homeostasis. A subcontract with the University of Pittsburgh will support complementary statistical analyses and genetic expertise.

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