Project Grant R01DK139594

Award Date 7/1/25
Completion Date 3/31/29
Dollars Obligated $384K
Federal Grant Program
93.847
Assistance Type
Project Grant
Place of Performance
Atlanta, GA 30322, USA
Similar Awards
This federal Project Grant award for $273,000.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award supports research to investigate the role of phospholipid homeostasis in cellular and organismal physiology, with a focus on understanding the function of the choline transporter protein FLVCR1 and its impact on mitochondrial function and cellular stress...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $534,160 to support research on the molecular mechanisms underlying protein function. The key focus areas include: Elucidating the mechanisms by which ion transport proteins, such as TMEM175, CLC, IP3Rs, and CLN7, recognize and transport ions across cellular membranes, as well as how their activities are regulated. Investigating...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $555,595.00 to Duke University to investigate the endocytic mechanisms in lysosome-rich enterocytes that support dietary protein absorption in the neonatal mammalian gut. The research aims to elucidate the specialized form of clathrin-mediated endocytosis that enables these...
This federal Project Grant award, valued at $1,618,520.00, was made by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research to define the molecular mechanisms and physiological role of a novel lysosomal pathway of adipocyte lipolysis, which may provide new insights into the regulation of systemic lipid metabolism and its implications for...
This Project Grant award of $418,560 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research to evaluate the therapeutic potential of a new orally active small molecule in obesity-linked diabetic models. The primary objectives are to: Analyze the pharmacokinetic profiles and investigate the efficacy and mechanisms of the new small molecule in improving...
This $553,545 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research program supports research aimed at understanding the mechanisms that regulate allelic expression of the Gsα subunit of the stimulatory G protein, and how this impacts hormone signaling and the development of diseases like pseudohypoparathyroidism. The principal investigator and awardee, The...
This $400,820 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports the development of genetically encoded chloride sensors to measure sodium-chloride transport in the kidneys of live mice. The research, conducted by Wayne State University, aims to generate transgenic mouse lines expressing chloride-sensing probes that will enable the monitoring of...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will fund research to investigate the role of two peroxisomal PEX family proteins, PEX6 and PEX14, in regulating hepatic bile acid and lipid metabolism. The $130,607 award, with a performance period from August 21, 2024 to June 30, 2027, will be carried out by the University of California,...
This Project Grant award, valued at $240,725.00, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The purpose of the research is to investigate how proinflammatory cytokines disrupt pancreatic beta-cell Golgi structure and function, which may explain early defects in beta-cell secretory function observed in type 1 diabetes. Specifically, the project aims to...
The National Institute of General Medical Sciences (NIGMS) awarded a $743,818 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the Georgia Tech Research Corporation. The award, which runs from August 1, 2024 to July 31, 2029, supports research to identify the fundamental biochemical mechanisms underlying lipid metabolism and the role of membrane proteins in metabolizing lipids and lipid-like xenobiotics such as cannabinoids. Key objectives include...

This Project Grant award of $384,414 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) will support research by Emory University to investigate the role of electrostatic forces in the interaction of membrane proteins and charged membrane lipids. Specifically, the project will examine the interaction of the membrane-associated protein MARCKS-like Protein-1 (MLP-1) and the epithelial sodium channel (ENaC) with the anionic lipid phosphatidylinositol 4,5-bisphosphate (PIP2). The research aims to understand how these molecular interactions regulate ENaC activity and stability within specialized membrane domains. The award period runs from July 1, 2025 to March 31, 2029.

Generated 6/24/25, 4:58 AM