This $806,452 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research investigating the mechanisms that combine type 2 diabetes and non-alcoholic fatty liver disease (NAFLD). The research aims to determine how hepatic insulin resistance can lead to the progression of NAFLD to the more severe non-alcoholic steatohepatitis (NASH), and how this...
This $272,133 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research to study the role of lipid droplet proteins in regulating polyunsaturated fatty acid metabolism and eicosanoid production, and their impact on the progression of non-alcoholic fatty liver disease (NAFLD). The principal investigator will conduct a "recall-by-genotype" study to deeply...
The U.S. National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a Project Grant (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) to the Icahn School of Medicine at Mount Sinai totaling $707,389.00 on August 15, 2024. The grant supports a 5-year study titled "Targeting Nonalcoholic Fatty Liver Disease During the Reproductive Period to Improve Women's Health Outcomes". The study aims to: 1) Determine the association between...
The federal Project Grant award R01DK140159, funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to investigate the potential of a novel adipokine in resolving non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) in animal models. The $469,235 award, with a start date of September 1, 2024, and an ultimate completion date of June 30,...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $243,590 to the University of Chicago to investigate the role of the protein BNIP3 in regulating lipid homeostasis in the liver. The goal is to define the mechanisms by which BNIP3 influences the accumulation of lipid droplets, which is a key factor in the development of non-alcoholic...
This federal Project Grant award of $675,660.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award was granted to the Beth Israel Deaconess Medical Center, Inc. (Bidmc) to conduct research focused on understanding the regulation and requirements for coenzyme A (CoA) biosynthesis, and how dysregulation of CoA synthesis is related to metabolic diseases...
This federal Project Grant award of $1,618,520.00 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research to define the molecular and physiological mechanisms of a novel lysosomal lipolysis pathway in adipocytes. The principal objectives are to: 1) Elucidate the molecular and cell biological mechanisms governing fatty acid mobilization from adipocytes during fasting via lysosomal...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $1,428,186 Project Grant under CFDA 93.847 (Diabetes, Digestive, and Kidney Diseases Extramural Research) to Beth Israel Deaconess Medical Center, Inc. (Bidmc) in Boston, MA. The grant, effective January 1, 2025 through December 31, 2029, will fund research to biochemically characterize N-acyl amino acids as substrates and competitive inhibitors of CYP4F enzymes, define the functional consequences of N-acyl...
This federal Project Grant award of $692,243 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research program, aims to explore the role of the hepatic lymphatic system in cholestatic liver diseases. The key objectives are to: 1) Determine the role of the hepatic lymphatic system in cholestatic liver disease, 2) Elucidate the mechanism of bile acid-driven hepatic lymphangiogenesis, and...
The U.S. National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $222,500 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to the Beckman Research Institute of the City of Hope. The grant supports research to understand how conjugated bile acids regulate metabolism after bariatric surgery, with the goal of developing safer and more affordable treatments for obesity and fatty liver disease. Key activities include...