The U.S. National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $222,500 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to the Beckman Research Institute of the City of Hope. The grant supports research to understand how conjugated bile acids regulate metabolism after bariatric surgery, with the goal of developing safer and more affordable treatments for obesity and fatty liver disease. Key activities include...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) provides $243,590 to the University of Chicago to study the role of the mitophagy receptor BNIP3 in regulating lipid homeostasis in the liver. The goal is to define the mechanisms by which BNIP3 decreases lipid droplet content through promoting mitophagy and lipophagy, particularly in the...
This Project Grant award of $949,056, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research by Northwestern University to investigate the functional roles of the DDX41 gene in the homeostasis of G-quadruplexes during erythropoiesis. The research aims to elucidate the molecular and cellular mechanisms by which DDX41 mutations contribute to the...
This $626,429 Project Grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) supports research to investigate the role of the carbohydrate responsive element binding protein (CHREBP) and its isoforms in liver metabolism and metabolic disorders. The project aims to resolve contradictory findings on CHREBP's effects and better understand its influence on conditions like metabolic-associated steatohepatitis, dyslipidemia, and cardiometabolic diseases....
This federal Project Grant award of $444,867.00 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to investigate the role of the UPR transducer XBP1 in pancreatic beta cell survival and function under metabolic stress. The research will use a novel mouse model to elucidate the pathological role of XBP1s in beta cell integrity under metabolic stress, in order to...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $172,300.00 to the University of California, Los Angeles (UCLA) to investigate the role of peroxisomal PEX family proteins, specifically PEX6 and PEX14, in regulating hepatic bile acid and lipid metabolism. The research aims to determine how disrupting these PEX proteins affects the...
This Project Grant award of $1,908,038 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will support research to advance the understanding of the role of the apical sodium-dependent bile acid transporter (ASBT) in the pathogenesis of cholestatic liver disease and associated kidney injury. The research aims to elucidate the therapeutic mechanisms of action of...
This Project Grant award of $847,746 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research to investigate the role of the UPR transducer XBP1 in pancreatic beta cell survival and function under metabolic stress. The research aims to elucidate the impact of XBP1S overexpression on beta cell integrity and the potential mechanisms underlying dynamic beta cell...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $124,536 to investigate the role of branched-chain amino acid (BCAA) metabolism in regulating adiposity during systemic hypoxia. The research aims to elucidate the mechanisms underlying the reprogramming of BCAA metabolism in adipose tissue under oxygen deprivation, and to determine the...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $938,470 to the University of Massachusetts Medical School to investigate a novel adipokine that may resolve non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) in mouse models. The award period runs from September 1, 2024 to June 30, 2028. The research aims...