The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $1,930,758 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to Sylvatica Biotech Inc., a minority-owned small business. The funding supports the research and development of "enhanced supercooling" techniques to enable extended preservation of clinical-scale human and porcine livers at high subzero temperatures for more than 72 hours. The...
This Project Grant award of $3,740,270 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports the development of a platform for extended kidney preservation via subnormothermic perfusion. The award aims to optimize the engineering of the platform, evaluate the impact of warm ischemic injury and duration of preservation on kidney graft injury, and compare the function...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $443,432 Project Grant (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) to Michigan Technological University to develop liver organoids with integrated bile ducts for therapeutic applications. The objective is to evaluate and optimize the effects of patterned Notch signaling and biomechanical cues on co-cultured liver cells to create liver organoids with a functional bile-flow...
This federal Project Grant award of $683,339 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research to understand and engineer cell competition and fitness to combat chronic liver diseases. The key objectives are to: Uncover the mechanism of cell competition in the liver using a rat cell transplantation model and modulated hepatocytes. Investigate the liver...
This federal Project Grant award, valued at $748,049.00 and granted by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to perform a multi-center validation and biological assessment of a novel pre-transplant biomarker panel to predict mortality risk in liver transplant recipients. The principal investigator is Rutgers, The State University of New Jersey, which will lead...
This Project Grant award, ID R01DK141602, is funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The total award amount is $726,019.00, with a project period from December 15, 2024 to November 30, 2028. The primary objective of this research is to investigate how changes in transcription factor dynamics and heterochromatin states impact liver development,...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $866,290 to Rutgers, The State University of New Jersey to characterize the molecular pathways by which hypothermic oxygenated machine perfusion (HMP-O2) mitigates preservation injury in liver transplantation. The research aims to: 1) define the protective pathways activated by HMP-O2 compared to static cold storage...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $754,400.00 to The University of Texas Southwestern Medical Center to conduct research aimed at identifying adaptive genetic pathways and mutant clones that could potentially protect against chronic liver disease progression. The key products and services to be delivered under this 5-year...
The University of Louisville, through its Office of Research & Innovation Division, received a $464,073 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) to develop a generative AI-based system for accurate prediction of deceased donor liver-transplant (DDLT) outcomes and viability. The proposed system will use deep learning techniques to produce "virtual" Masson's trichrome stained slides from input hematoxylin and eosin...
This Project Grant award of $182,689 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under CFDA program 93.847 (Diabetes, Digestive, and Kidney Diseases Extramural Research) will fund research on survivorship trajectories after liver transplantation. The grant aims to: 1) characterize distinct post-liver transplant survivorship phenotypes, 2) investigate the relationship between survivorship phenotypes and outcomes like medication adherence and quality of...