This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), provides $583,289 to the University of Arkansas for Medical Sciences to conduct research on the epigenetic regulation of Kaposi's sarcoma-associated herpesvirus (KSHV) latency. The research aims to advance understanding of how KSHV, which causes several AIDS-defining malignancies including Kaposi's sarcoma, can...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $466,640 to the University of Florida to investigate the mechanisms by which oral bacteria and their metabolites support Kaposi's sarcoma-associated herpesvirus (KSHV) infection in oral epithelial cells. The goal is to determine how bacterial factors, such as short-chain fatty acids, can upregulate cellular stress...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), is providing $1,337,014 over approximately 5 years starting September 1, 2024 to investigate the mechanisms by which Kaposi's Sarcoma-Associated Herpesvirus (KSHV) manipulates cellular metabolism to facilitate viral replication and tumor growth. The key research objectives are to: 1) Determine how KSHV's viral cyclin protein...
This $306,000 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will support research to determine the role of Macrophage Migration Inhibitory Factor (MIF) signaling in Kaposi's Sarcoma-associated Herpesvirus (KSHV) pathogenesis and oncogenesis. The research aims to: 1) Determine the mechanisms of MIF signaling activation in KSHV-positive tumor cells, and 2) Develop MIF-targeted...
This federal Project Grant award, with ID R01CA290700, was provided by the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396). The $564,698 award to the University of California, Davis (UC Davis) will fund a 5-year research project to investigate the role of the terminal repeat sequence in regulating the Kaposi's sarcoma-associated herpesvirus (KSHV) lytic gene promoters. The research aims to better understand the KSHV gene regulation mechanisms, with the...
This Project Grant award of $877,104 from the National Institute of Allergy and Infectious Diseases (NIAID) under CFDA 93.855 Allergy and Infectious Diseases Research supports research to investigate the interactions between Kaposi's sarcoma-associated herpesvirus (KSHV), mononuclear phagocytes, and B cells, and how KSHV establishes long-term latency in B cells. The research, conducted by Brigham & Women's Hospital, a subsidiary of Partners Healthcare System, will use computational...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $548,660 Cooperative Agreement under the Oral Diseases and Disorders Research (CFDA 93.121) program to the University of California, Davis. The project aims to develop innovative laboratory techniques and computational methods to overcome major challenges in identifying and characterizing human viruses. Key objectives include optimizing methods for recovery and quantification of RNA and DNA viruses from human stool...
This Project Grant award of $155,500 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will support a comprehensive examination of the oral virome and its interactions with the oral microbiome. The research aims to shed light on the role of viruses in maintaining oral health and contributing to disease, with the goal of illuminating a neglected aspect of the oral microenvironment and potentially...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a Project Grant (CFDA 93.121 - Oral Diseases and Disorders Research) to the University of Arizona in the amount of $118,763 for the period of September 1, 2024 to August 31, 2026. The grant will support Dr. Robert Jackson's research focused on assessing the role of human papillomavirus type 16 (HPV16) in transforming versus productive infections in oral epithelial tissues. The research aims to characterize the viral...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), is providing $180,943 to the University of California, Los Angeles (UCLA) to conduct research on therapeutic targeting of apical periodontal T-cells in chronic oral inflammation. The key objectives are to: 1) establish the physiological role of the ORAI1 protein in apical periodontitis, 2) determine the ORAI-dependent...