Project Grant R01DE035393

Award Date 7/1/25
Completion Date 6/30/30
Dollars Obligated $483K
Federal Grant Program
93.121
Assistance Type
Project Grant
Place of Performance
California, USA
Similar Awards
This Project Grant award of $707,526 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research to investigate mechanisms that contribute to poor response to epidermal growth factor receptor (EGFR) inhibition therapies in head and neck squamous cell carcinoma (HNSCC) patients receiving radiotherapy. The key research objectives are to determine if interleukin-1 (IL-1)-mediated NADPH oxidase 2...
This $392,187 Project Grant award from the National Cancer Institute's Cancer Biology Research (CFDA 93.396) program supports research at the University of California, San Diego (UCSD) to investigate how changes in the mechanical properties of the tumor microenvironment contribute to the invasive and metastatic behavior of oral squamous cell carcinoma (OSCC). The project aims to elucidate the mechanisms by which tumor stiffness induces the acquisition and consolidation of "mechanical...
This Project Grant award from the National Cancer Institute (CFDA 93.395 Cancer Treatment Research) provides $699,929 to the University of California, San Diego (UCSD) to conduct research aimed at enhancing dendritic cell migration to draining sentinel nodes in order to improve immunotherapy response in human papillomavirus (HPV) negative head and neck squamous cell carcinoma (HNSCC). The research project seeks to define the functional state of dendritic cells in tumor and draining sentinel...
This federal Project Grant award of $429,000.00 was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research (CFDA 93.121) program. The grant supports research to determine the functional roles and mechanisms of the human microbiome and metabolome in the pathogenesis of oral squamous cell carcinoma (OSCC), a prevalent and lethal form of head and neck cancer. The research aims to 1) define OSCC-associated metagenomic and...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $164,322 to the Regents of the University of Michigan to investigate the evolution of pro-tumoral myeloid cells during the initiation of oral cancer. The researchers will utilize a preclinical mouse model to study the transition from oral epithelial dysplasia to head and neck squamous cell carcinoma, with a focus on...
This Project Grant award of $229,440 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research to investigate the mechanisms driving differential responses to a novel radio-immunotherapy combination in preclinical models of head and neck squamous cell carcinoma (HNSCC) and pancreatic adenocarcinoma (PDAC). The research aims to elucidate how regulatory T cells mediate the divergent responses...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $808,264 Project Grant under the Oral Diseases and Disorders Research (CFDA 93.121) federal grant program to The Medical University of South Carolina. The grant aims to elucidate the mechanisms underlying filopodia-mediated intracellular uptake of a cell-penetrating peptide (RD3AD) complex carrying small interfering RNAs (siRNAs), and to determine its ability to target and deliver siRNAs to migrating/invading oral...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $1,403,398 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to The General Hospital Corporation (Massachusetts General Hospital) to conduct research on precision imaging approaches for understanding the spatial regulators of the hybrid epithelial/mesenchymal state in head and neck cancer. The project aims to utilize advanced imaging techniques to investigate how the hybrid...
This $390,000 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research to identify tumor antigen-specific T cells in oral squamous cell carcinoma (OSCC). The key products and services to be delivered include: Developing a high-throughput, single-cell co-culture system to isolate individual tumor-killing T cells and identify their T cell receptors (TCRs). Performing...
This federal Project Grant award in the amount of $469,830.00 was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121). The grant aims to identify oral bacterial species with anti-cancer properties and evaluate their potential for preventing or treating oral squamous cell carcinoma (OSCC). Specifically, the study will assess the effects of Streptococcus mitis and Haemophilus parainfluenzae on OSCC...

This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $483,360 to the University of California, San Diego (UCSD) to conduct research aimed at identifying new precision therapies for oral cancer. The key focus is to exploit vulnerabilities in the EGFR/HER3/HER2 oncogenic signaling circuitry to disrupt immune evasive mechanisms and enhance the activity of anti-PD-1 immunotherapies for head and neck squamous cell carcinoma (HNSCC). The award has a period of performance from July 1, 2025 to June 30, 2030. The research will be primarily conducted at UCSD.

Generated 8/5/25, 5:54 AM