This federal Project Grant award in the amount of $469,830.00 was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121). The grant aims to identify oral bacterial species with anti-cancer properties and evaluate their potential for preventing or treating oral squamous cell carcinoma (OSCC). Specifically, the study will assess the effects of Streptococcus mitis and Haemophilus parainfluenzae on OSCC...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $2,805,385 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to Oregon Health & Science University (OHSU). The grant aims to define the T cell-based mechanisms underlying oral mucosal immune-related adverse events (irAEs) caused by anti-PD-1 cancer immunotherapy, with the goal of developing strategies to mitigate these side effects. The research will utilize human samples, mouse...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $164,322 to the Regents of the University of Michigan to conduct research on intercepting the evolution of pro-tumoral myeloid cells during the initiation of oral cancer. The research aims to investigate how SOX2-driven malignant transformation impacts STING signaling in tumor-resident immune cells, using a preclinical...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $163,411 Project Grant under the Oral Diseases and Disorders Research (CFDA 93.121) federal grant program to The Ohio State University. The grant supports research to understand the interactions between Streptococcus mutans, a primary driver of dental caries, and other commensal oral bacteria. The research aims to explicate the nutritional niches and carbohydrate utilization preferences of these microbes within oral...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a Project Grant (CFDA 93.121 - Oral Diseases and Disorders Research) in the amount of $473,632 to the University of Toledo on May 1, 2025. The purpose of this 3-year project is to investigate the role of megakaryocytes (MEGs) and their response to the cytokine interleukin-17 (IL-17) in oral mucosal immunity, particularly during oropharyngeal candidiasis caused by Candida albicans. The research aims to elucidate the...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $1,564,226 Project Grant (CFDA 93.121 - Oral Diseases and Disorders Research) to Virginia Commonwealth University (VCU) to investigate the role of FOSL1 super-enhancers in cisplatin-enriched cancer stem cells (CSCs) in head and neck squamous cell carcinoma (HNSCC). The key objectives are to: 1) examine the mechanism by which FOSL1 super-enhancers determine the functional properties of cisplatin-enriched CSCs, and...
This $598,332 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research (CFDA 93.121) program, will support research to investigate the role of the truncated TrkB isoform (TrkBT1) in oral cancer pain. The primary awardee, the University of Texas Health Science Center at San Antonio (UTHSCSA), will conduct studies to examine how TrkBT1 expressed in trigeminal sensory neurons and oral squamous cell carcinoma (OSCC)...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research Federal Grant Program (CFDA 93.121), will fund research to define oral squamous cell carcinoma (OSCC)-associated microbiome and metabolome signatures and determine if microbiota transfer from OSCC patients to mouse models promotes tumorigenesis. The $234,000 award to the University of Colorado-Denver will extend previous studies on the role of the human...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $226,500 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to The Medical University of South Carolina. The grant, titled "CD38 Signaling in Aging-Associated Immune Responses Induced by Oral Pathogens," aims to define how oral pathogens affect aging-associated immune responses and determine if inhibition of the CD38 enzyme can alleviate inflammatory bone loss and...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $162,743 to New York University (NYU) to conduct research on the role of Schwann cells and the TRPV4 ion channel in oral cancer pain mechanisms. The 5-year award, which commenced on March 10, 2025, aims to develop and validate new methods for measuring pressure and stretch sensitivity associated with oral cancer...