Project Grant R01DE033632

Award Date 9/1/24
Completion Date 5/31/29
Dollars Obligated $1.3M
Federal Grant Program
93.121
Assistance Type
Project Grant
Place of Performance
Cleveland, OH 44195, USA
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The key research objectives are to: 1) Determine how KSHV's viral cyclin protein hijacks the cellular CDK6 kinase to phosphorylate and regulate metabolic enzymes involved in glycolysis, nucleotide synthesis, and fatty acid synthesis; 2) Delineate the KSHV-driven reprogramming of these core metabolic pathways mediated by the viral cyclin-CDK6 complex; and 3) Assess the physiological relevance of CDK6-dependent metabolic reprogramming in KSHV pathogenesis.

The project involves a sub-award to Arizona State University to perform advanced metabolomics and metabolic flux analyses on cell and tissue samples from the in vitro and in vivo experiments. This collaborative effort aims to elucidate the unprecedented mechanisms by which KSHV exploits host cellular metabolism to promote viral persistence and tumorigenesis, which could inform the development of novel therapeutic approaches.

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